Common pharmacological therapies for gastrointestinal diseases, e.g., inflammatory bowel diseases, irritable bowel syndrome and colon cancer, continue to show challenges in targeting efficacy. Moreover, current conventional oral therapies present different adverse effects associated with systemic exposure. Bertoni et al. summarize innovative approaches to overcoming these drawbacks using disease‐targeted drug delivery systems, including the production and characterization of the nanoplatforms. The smart nanomaterials described respond to increased levels of reactive oxygen species (ROS) concentrated in the inflamed areas, as well as to other more commonly used stimuli, for instance variation of pH value. (DOI: 10.1002/bip.23336)

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胃肠道疾病（例如炎性肠病，肠易激综合症和结肠癌）的常用药理疗法继续显示出靶向疗效方面的挑战。此外，当前的常规口服疗法表现出与全身暴露相关的不同不良作用。Bertoni等。总结了使用针对疾病的药物输送系统克服这些缺陷的创新方法，包括纳米平台的生产和表征。所描述的智能纳米材料对发炎地区集中的活性氧（ROS）水平升高以及其他更常用的刺激（例如pH值变化）作出反应。（DOI：10.1002 / bip.23336）