The pharmacological properties of a drug, e.g., bioavailability, distribution and metabolism, reflect its association with plasma proteins. Kabiru A. Musa et al. report on the interaction between mefloquine (MEF), the antimalarial drug, and human serum albumin (HSA), the main carrier protein in blood circulation. Data from fluorescence, absorption, and circular dichroism spectroscopies reveal the formation of a MEF‐HSA complex with moderate binding affinity, involving hydrophobic interactions and hydrogen bonds. Site marker competitive drug displacement results along with molecular docking analysis suggest HSA Sudlow's site I as the MEF binding site. (DOI: 10.1002/bip.23337)

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药物的药理特性，例如生物利用度，分布和代谢，反映了它与血浆蛋白的关系。Kabiru A.Musa等。报告了抗疟药甲氟喹（MEF）和血液循环中的主要载体蛋白人血清白蛋白（HSA）之间的相互作用。来自荧光，吸收和圆二色性光谱的数据揭示了具有中等结合亲和力的MEF-HSA复合物的形成，涉及疏水相互作用和氢键。站点标记竞争性药物置换结果以及分子对接分析表明，HSA Sudlow的站点I为MEF结合位点。（DOI：10.1002 / bip.23337）