Human calcitonin (hCT) is a 32‐residue peptide hormone that is produced in the thyroid where it regulates blood calcium levels and promotes bone formation. While hCT was previously used to treat bone disorders, this has ceased because hCT has been shown to aggregate when elevated levels of the peptide are either produced naturally or injected, and the resulting amyloid fibrils toxic. Deguo Du and his team report the effects of cholesterol, cholesterol sulfate and 3β‐[N‐ (dimethylaminoethane) carbamoyl]‐ cholesterol (DC‐cholesterol) on oxidised hCT, revealing an inhibitory effect of DC‐cholesterol on amyloidogenesis. The results provide mechanistic information on the interactions at play and may aid the design of steroid‐based structures for inhibiting hCT aggregation. (DOI: 10.1002/bip.23343)

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降钙素（hCT）是一种32残基的肽激素，在甲状腺中产生，可调节血钙水平并促进骨骼形成。尽管以前曾用hCT来治疗骨疾病，但由于已经显示出当天然产生或注射升高水平的肽时hCT会聚集，并且所得淀粉样蛋白原纤维具有毒性，因此hCT已停止。Deguo Du和他的团队报告了胆固醇，硫酸胆固醇和3β-[N-（二甲基氨基乙烷）氨基甲酰基]-胆固醇（DC-胆固醇）对氧化hCT的影响，揭示了DC-胆固醇对淀粉样蛋白生成的抑制作用。结果提供了有关相互作用的机制信息，可能有助于设计基于类固醇的结构来抑制hCT聚集。（DOI：10.1002 / bip.23343）