Strain Rate Imaging (SRI) is one of the most used techniques to study left atrial (LA) and diastolic function. Its availability in low-income countries is diminished since it requires additional expensive software, among other limitations. In contrast, Tissue Doppler Imaging (TDI) is widely available and easy to use. We hypothesize TDI could detect changes in LA and diastolic function associated with age similarly to SRI. The aim of this study is to evaluate the effects of age on LA and diastolic function assessed by LA lateral wall TDI online by spectral pulse, and to compare them with age-related variations of LA SRI and other parameters of diastolic function in a population of healthy adults. Ninety-one healthy adults were prospectively evaluated. In apical four - chamber view the LA lateral wall was divided in three portions. Peak velocities of basal and mid portions were measured with TDI online by spectral pulse and with SRI by speckle tracking. A first positive wave (S’la and SRS) and two negative waves (E’la and SRE, and A’la and SRA respectively) were obtained. E’la/A’la ratio and SRE/SRA ratio were analyzed. The distribution of the variables by age subgroups was described and analyzed. Correlation analyses were performed. The median age was 42 years old and 54.9% were female. E’la/A’la showed a negative good correlation with age. E’la/A’la and SRE/SRA ratios changed from > 1 to < 1 in the age group of 41–50 years old, while this occurred in the group of 51–60 years old for the E/A ratio. Lateral and septal mitral annulus E´ showed decrease with age and prolongation of E-wave deceleration time was observed in the age group over 61 years old. Normal values​​ according to age group of TDI of the LA lateral wall were obtained. Age-related changes in LA and diastolic function could be detected as early with TDI as with SRI. Future studies are required to explore if this method could be used to address in part LA or diastolic function in other populations with established cardiovascular disease or at risk of presenting it, which could be useful in low-income settings, where SRI is not available.

中文翻译：

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左心房侧壁的组织多普勒成像和应变率：年龄相关的变化和与舒张功能参数的比较。

应变率成像 (SRI) 是研究左心房 (LA) 和舒张功能最常用的技术之一。它在低收入国家的可用性降低，因为它需要额外的昂贵软件以及其他限制。相比之下，组织多普勒成像 (TDI) 应用广泛且易于使用。我们假设 TDI 可以检测与 SRI 类似的 LA 和与年龄相关的舒张功能的变化。本研究的目的是评估年龄对 LA 和 LA 侧壁 TDI 通过光谱脉冲在线评估的舒张功能的影响，并将其与 LA SRI 和其他舒张功能参数的年龄相关变化进行比较。健康的成年人。对 91 名健康成年人进行了前瞻性评估。在心尖四腔观中，LA 侧壁被分成三部分。基部和中部的峰值速度通过光谱脉冲在线 TDI 和斑点跟踪 SRI 测量。获得了第一个正波（S'la 和 SRS）和两个负波（分别是 E'la 和 SRE，以及 A'la 和 SRA）。分析了 E'la/A'la 比率和 SRE/SRA 比率。描述和分析了各年龄亚组的变量分布。进行了相关分析。中位年龄为 42 岁，54.9% 为女性。E'la/A'la 与年龄呈负相关。E'la/A'la 和 SRE/SRA 比值在 41-50 岁年龄组中从 > 1 变为 < 1，而这发生在 51-60 岁组的 E/A 比值。外侧和间隔二尖瓣环 E' 显示随着年龄的增长而减少，并且在 61 岁以上的年龄组中观察到 E 波减速时间延长。获得了根据 LA 侧壁 TDI 年龄组的正常值。与 SRI 一样，TDI 可以尽早检测到 LA 和舒张功能的年龄相关变化。未来的研究需要探讨这种方法是否可用于部分解决已患有心血管疾病或有患心血管疾病风险的其他人群的 LA 或舒张功能，这在没有 SRI 的低收入环境中可能有用。