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FRX proteins bring new perspectives to nucleoporins' homeostasis.
The EMBO Journal ( IF 9.4 ) Pub Date : 2020-09-11 , DOI: 10.15252/embj.2020106510
Guillaume Holzer 1 , Wolfram Antonin 1
Affiliation  

FXR proteins are part of ribonucleoprotein granules controlling stability, translation, and cellular localization of target mRNAs. In the current issue, Agote‐Aran et al extend the repertoire of FXR protein action and show that they are also involved in the transport of nuclear pore complex components to the nuclear envelope and thereby prevent cytoplasmic aggregation of these proteins.

中文翻译:

FRX 蛋白为核孔蛋白的稳态带来了新的视角。

FXR 蛋白是核糖核蛋白颗粒的一部分,控制目标 mRNA 的稳定性、翻译和细胞定位。在本期杂志中,Agote-Aran等人扩展了 FXR 蛋白作用的所有组成部分,并表明它们还参与将核孔复合物组分转运至核膜,从而防止这些蛋白在细胞质中聚集。
更新日期:2020-10-15
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