Background: The combination of radiotherapy (RT) and chemotherapy, as a standard treatment for breast cancer in the clinic, is unsatisfactory due to chemoradioresistance and severe side effects.
Methods and Results: To address these issues, a cancer cell-erythrocyte hybrid membrane-coated doxorubicin (DOX)-loaded gold nanocage (CM-EM-GNCs@DOX) was constructed for near-infrared light (NIR)-activated photothermal/radio/chemotherapy of breast cancer. CM-EM-GNCs@DOX inherited an excellent homologous target ability from the cancer cell membrane and an immune evasion capability from the erythrocyte membrane, together resulting in highly efficient accumulation in the tumor site with decreased clearance. Following the highly efficient uptake of CM-EM-GNCs@DOX in cancer cells, the RT efficacy was remarkably amplified due to the radiosensitization effect of CM-EM-GNCs@DOX, which reduced the needed radiotherapeutic dose. Importantly, with NIR irradiation, CM-EM-GNCs@DOX exerted a high photothermal effect, which not only ruptured CM-EM-GNCs@DOX to release DOX for precise and controllable chemotherapy, but also potentiated chemo/radiotherapy by photothermal therapy.
Conclusion: Therefore, a highly efficient and safe combined photothermal/radio/chemotherapy approach was achieved in vitro and in vivo by CM-EM-GNCs@DOX, which provided a promising strategy for treating breast cancer.



中文翻译：

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用于乳腺癌近红外光激活光热/放射/化疗的癌细胞-红细胞混合膜包覆金纳米笼

背景：放疗（RT）和化疗联合作为临床上乳腺癌的标准治疗方法，由于放化疗耐药和严重的副作用而不能令人满意。
方法和结果：为了解决这些问题，构建了一种癌细胞-红细胞混合膜包覆阿霉素（DOX）负载金纳米笼（CM-EM-GNCs@DOX），用于近红外光（NIR）激活的乳房光热/放射/化疗癌症。CM-EM-GNCs@DOX 继承了癌细胞膜的优异同源靶向能力和红细胞膜的免疫逃避能力，共同导致在肿瘤部位高效积聚，清除率降低。随着 CM-EM-GNCs@DOX 在癌细胞中的高效摄取，由于 CM-EM-GNCs@DOX 的放射增敏作用，放疗的疗效显着增强，从而减少了所需的放射治疗剂量。重要的是，在近红外照射下，CM-EM-GNCs@DOX 发挥了高光热效应，
结论：因此，CM-EM-GNCs@DOX在体外和体内实现了一种高效、安全的光热/放射/化疗联合治疗方法，为治疗乳腺癌提供了一种有前景的策略。