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Iodinated polymer nanoparticles as contrast agent for spectral photon counting computed tomography.
Biomaterials Science ( IF 5.8 ) Pub Date : 2020-09-11 , DOI: 10.1039/d0bm01046d Joëlle Balegamire 1 , Marc Vandamme , Emmanuel Chereul , Salim Si-Mohamed , Samira Azzouz Maache , Eyad Almouazen , Laurent Ettouati , Hatem Fessi , Loïc Boussel , Philippe Douek , Yves Chevalier
Biomaterials Science ( IF 5.8 ) Pub Date : 2020-09-11 , DOI: 10.1039/d0bm01046d Joëlle Balegamire 1 , Marc Vandamme , Emmanuel Chereul , Salim Si-Mohamed , Samira Azzouz Maache , Eyad Almouazen , Laurent Ettouati , Hatem Fessi , Loïc Boussel , Philippe Douek , Yves Chevalier
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Suspensions of iodinated polymer nanoparticles are evaluated as contrast agent for Computed Tomography (CT) and Spectral Photon Counting Computed Tomography (SPCCT). Iodine containing moieties are grafted to poly(vinyl alcohol) by means of a covalent ester bond up to high degree of substitution of 0.77 providing high iodine content of 71 wt%. Polymer nanoparticles of 150 nm diameter stabilized by the block copolymer poly(caprolactone)-b-poly(ethylene glycol) are highly stable in water and human serum. High coverage of nanoparticles by PEG chains in a dense brush conformation (0.30 molecules·nm−2) provides resistance against fast elimination by mononuclear phagocytes system. Iodine concentration is increased up to 100 mg(I)·mL−1 by a centrifugation/redispersion step, which sets radiopacity of the contrast agent in the right range for imaging cardiovascular system and biodistribution. SPCCT ‘Material Decomposition’ and ‘K-edge reconstruction’ methods allow accurate quantification of iodine, as well as specific discrimination of iodine and gadolinium in mixed phantom samples. Intravenous injection of iodinated polymer nanoparticles to rats provides a clear visualization of the cardiovascular system over several hours followed by progressive accumulation in liver and spleen. This material is a ‘blood pool’ contrast agent with very long residence time in the blood stream.
中文翻译：
碘化聚合物纳米粒子作为用于光谱光子计数计算机断层扫描的造影剂。
碘化聚合物纳米颗粒的悬浮液被评估为计算机断层扫描（CT）和光谱光子计数计算机断层扫描（SPCCT）的造影剂。含碘部分通过共价酯键接枝到聚乙烯醇上，最高取代度为0.77，从而提供71 wt％的高碘含量。通过嵌段共聚物聚己内酯-b-聚乙二醇稳定的直径为150 nm的聚合物纳米粒子在水和人血清中高度稳定。PEG链以密集的刷状构型（0.30分子·nm -2）对纳米颗粒的高覆盖度提供了抵抗单核吞噬细胞系统快速消除的能力。碘浓度增加到100 mg（I）·mL -1通过离心/再分散步骤，可将造影剂的射线不透性设定在合适范围内，以对心血管系统和生物分布成像。SPCCT的“材料分解”和“ K边缘重建”方法可对碘进行精确定量，并可对混合体模样品中的碘和and进行特定区分。向大鼠静脉内注射碘化聚合物纳米颗粒可在数小时内清晰显示心血管系统，然后逐渐在肝脏和脾脏中蓄积。这种材料是“血池”造影剂，在血液中的停留时间非常长。
更新日期：2020-10-13
中文翻译：
碘化聚合物纳米粒子作为用于光谱光子计数计算机断层扫描的造影剂。
碘化聚合物纳米颗粒的悬浮液被评估为计算机断层扫描（CT）和光谱光子计数计算机断层扫描（SPCCT）的造影剂。含碘部分通过共价酯键接枝到聚乙烯醇上，最高取代度为0.77，从而提供71 wt％的高碘含量。通过嵌段共聚物聚己内酯-b-聚乙二醇稳定的直径为150 nm的聚合物纳米粒子在水和人血清中高度稳定。PEG链以密集的刷状构型（0.30分子·nm -2）对纳米颗粒的高覆盖度提供了抵抗单核吞噬细胞系统快速消除的能力。碘浓度增加到100 mg（I）·mL -1通过离心/再分散步骤，可将造影剂的射线不透性设定在合适范围内，以对心血管系统和生物分布成像。SPCCT的“材料分解”和“ K边缘重建”方法可对碘进行精确定量，并可对混合体模样品中的碘和and进行特定区分。向大鼠静脉内注射碘化聚合物纳米颗粒可在数小时内清晰显示心血管系统，然后逐渐在肝脏和脾脏中蓄积。这种材料是“血池”造影剂，在血液中的停留时间非常长。
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