Eco-friendly development of an ultrasmall IONP-loaded nanoplatform for bimodal imaging-guided cancer theranostics,Biomaterials Science

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Eco-friendly development of an ultrasmall IONP-loaded nanoplatform for bimodal imaging-guided cancer theranostics
Biomaterials Science ( IF 5.8 ) Pub Date : 2020-09-11 , DOI: 10.1039/d0bm00867b
Yulin Li _{1,

2,

3,

4,

5} , Ling Zheng _{1,

2,

3,

4,

5} , Lan Xiao _{6,

7,

8,

9,

10} , Liudi Wang _{1,

2,

3,

4,

5} , Jingyuan Cui _{1,

2,

3,

4,

5} , Dongyong Sha _{1,

2,

3,

4,

5} , Changsheng Liu _{1,

2,

3,

4,

5}

Affiliation

Success in disease therapy depends on precision medicines, where development of formulations with diagnostic and therapeutic functions is quite important. In this study, multifunctional theranostics based on a magnetic graphene oxide (GO) nanohybrid (GIPD) has been developed for magnetic resonance (MR) imaging-guided chemo-photothermal therapy of cancer. The GIPD is endowed with T₁/T₂ MR imaging capacity via precipitation of small-sized IONP nanoparticles (8.25 ± 2.25 nm) on GO nanosheets through a mild friendly way (60 °C for 1 h, no organic solvent). The obtained nanocomposite is then non-covalently decorated with phosphine oxide polyethylene glycol to improve biosafety. The final nanohybrid effectively loads doxorubicin as the model chemotherapeutic drug and is found to have in vivo T₁/T₂ MR bimodal imaging functions. Both the in vitro and in vivo results demonstrate that the GO-based nanoplatform displays a good remote photothermal effect, which can damage the dense shell of solid tumor tissue, thereby facilitating the delivery of anticancer drugs into tumor cells. Therefore, this theranostic nanoplatform enables a potent combined chemo-photothermal anticancer efficacy, holding great potential for exploitation of precision cancer therapy.

中文翻译：

用于双峰成像引导的癌症治疗学的超小型IONP纳米平台的环保开发

疾病治疗的成功取决于精密药物，其中具有诊断和治疗功能的制剂的开发非常重要。在这项研究中，已经开发了基于磁性氧化石墨烯（GO）纳米杂化物（GIPD）的多功能治疗药物，用于磁共振（MR）成像引导的化学光热疗法。所述GIPD被赋予Ť ₁ / Ť ₂ MR成像能力通过通过温和友好的方式（60°C放置1 h，无有机溶剂）在GO纳米片上沉淀小尺寸IONP纳米颗粒（8.25±2.25 nm）。然后将获得的纳米复合材料用氧化膦聚乙二醇非共价修饰，以提高生物安全性。最终的纳米杂化物有效地加载了阿霉素作为模型化学治疗药物，并且发现其具有体内T ₁ / T ₂ MR双峰成像功能。无论是在体外和体内结果表明，基于GO的纳米平台显示出良好的远程光热效应，可以破坏实体肿瘤组织的致密外壳，从而促进抗癌药物向肿瘤细胞的传递。因此，该治疗性纳米平台实现了强大的化学-光热抗癌联合疗效，为开发精确的癌症疗法具有巨大潜力。

更新日期：2020-11-03

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