An acidity-responsive polyoxometalate with inflammatory retention for NIR-II photothermal-enhanced chemodynamic antibacterial therapy,Biomaterials Science

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An acidity-responsive polyoxometalate with inflammatory retention for NIR-II photothermal-enhanced chemodynamic antibacterial therapy
Biomaterials Science ( IF 5.8 ) Pub Date : 2020-09-11 , DOI: 10.1039/d0bm01165g
Yunhao Shi _{1,

2,

3,

4,

5} , Jiajia Yin _{6,

7,

8,

9,

10} , Qinqin Peng _{6,

7,

8,

9,

10} , Xinyi Lv _{6,

7,

8,

9,

10} , Qinzhe Li _{6,

7,

8,

9,

10} , Dongliang Yang _{6,

7,

8,

9,

10} , Xuejiao Song _{6,

7,

8,

9,

10} , Wenjun Wang _{5,

11,

12,

13} , Xiaochen Dong _{1,

2,

3,

4,

5}

Affiliation

Subcutaneous abscesses caused by drug-resistant pathogens pose a serious challenge to human health. To overcome this problem, herein an acidity-responsive aggregated W/Mo-based polyoxometalate (POM) was developed for photothermal-enhanced chemodynamic antibacterial therapy in the second near-infrared (NIR) region. The POM can self-assemble into larger-sized aggregates with stronger absorption in the NIR region, making it remain in the acidic infected tissue. Furthermore, the hydrogen peroxide at the site of infection can be converted to a hydroxyl radical for chemodynamic therapy (CDT) and simultaneously the glutathione in organisms is consumed by the POM to further enhance the CDT effect. More importantly, under laser irradiation, the hyperthermia produced by the POM not only can kill drug-resistant Staphylococcus aureus, but also enhance the performance of CDT. Benefitting from the inflammatory retention and acidity-responsive photothermal-enhanced CDT properties, the POM exhibits an obvious therapeutic effect against drug-resistant bacterial infection without significant side effects under 1060 nm laser irradiation.

中文翻译：

NIR-II光热增强化学动力抗菌疗法的一种具有炎症反应性的酸敏感型多金属氧酸盐

耐药病原体引起的皮下脓肿对人类健康构成了严峻挑战。为了克服该问题，本文开发了酸度响应的聚集的基于W / Mo的多金属氧酸盐（POM）用于第二近红外（NIR）区域中的光热增强化学动力学抗菌疗法。POM可以自组装成较大的聚集体，并在NIR区域具有更强的吸收能力，使其保留在酸性感染组织中。此外，感染部位的过氧化氢可以转化为羟基，用于化学动力学治疗（CDT），同时有机物中的谷胱甘肽被POM消耗，以进一步增强CDT效果。更重要的是，在激光照射下，POM产生的高温不仅可以杀死耐药的金黄色葡萄球菌，还可以增强CDT的性能。得益于炎性保留和酸性反应性光热增强的CDT特性，POM在1060 nm激光照射下对耐药细菌感染表现出明显的治疗效果，而没有明显的副作用。

更新日期：2020-10-02

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