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Ethnic Differences Between Hispanics and Non-Hispanic Whites in Neuropsychiatric Symptoms Predict Conversion to Mild Cognitive Impairment.
Journal of Geriatric Psychiatry and Neurology ( IF 2.9 ) Pub Date : 2020-09-10 , DOI: 10.1177/0891988720957087
Bhaskar Thakur 1 , Luis Alvarado 2 , Christopher Dodoo 2 , Ricardo Salazar 3 , Alberto J Espay 4 , Alok Kumar Dwivedi 1, 2
Affiliation  

The aim of the study is to ascertain the neuropsychiatric symptoms (NPS) subtypes significantly influencing progression to mild cognitive impairment (MCI) by ethnicity. In this retrospective cohort study, we included 386 cognitively normal individuals participating in the longitudinal Texas Alzheimer’s Research and Care Consortium between February 2007 and August 2014. The primary outcome was time to incident MCI. Data driven NPS subtypes at baseline were identified and the effects of these subtypes on the outcome were obtained for Hispanic and non-Hispanic ethnic cohorts and summarized with a hazard ratio (HR). Three NPS subtypes were identified and internally validated: psychomotor apathy factor (including agitation, irritability, apathy), affective mood factor (including depression, anxiety), and physical behavior factor (including nighttime behavior, eating/appetite disturbances). In adjusted analysis, a psychomotor apathy score of NPS was the best predictor for MCI (HR = 2.19, p = 0.037) among non-Hispanics whereas physical behavior score was the most predictive of MCI (HR = 2.55, p = 0.029) among Hispanics. A high score of affective mood factor also tended to increase the risk of MCI (HR = 2.09, p = 0.06) in Hispanics. Progression from normal cognition to MCI was differentially predicted by NPS subtypes in Hispanics and non-Hispanic whites. These data may inform the allocation of efforts for monitoring individuals at-risk of MCI.



中文翻译:

西班牙裔和非西班牙裔白人在神经精神症状方面的种族差异预测转化为轻度认知障碍。

该研究的目的是确定神经精神症状 (NPS) 亚型显着影响种族轻度认知障碍 (MCI) 的进展。在这项回顾性队列研究中,我们纳入了 2007 年 2 月至 2014 年 8 月期间参与纵向德克萨斯阿尔茨海默病研究和护理联盟的 386 名认知正常的个体。主要结果是发生 MCI 的时间。确定了基线数据驱动的 NPS 亚型,并获得了这些亚型对西班牙裔和非西班牙裔种族队列结果的影响,并用风险比 (HR) 进行了总结。确定并内部验证了三种 NPS 亚型:精神运动性冷漠因素(包括激动、易怒、冷漠)、情感情绪因素(包括抑郁、焦虑)、和身体行为因素(包括夜间行为、饮食/食欲障碍)。在调整后的分析中,NPS 的精神运动冷漠评分是非西班牙裔中 MCI 的最佳预测指标(HR = 2.19,p = 0.037),而身体行为评分是西班牙裔中 MCI 的最佳预测指标(HR = 2.55,p = 0.029) . 在西班牙裔中,情感情绪因素的高分也倾向于增加 MCI 的风险(HR = 2.09,p = 0.06)。西班牙裔和非西班牙裔白人的 NPS 亚型对从正常认知到 MCI 的进展进行了不同的预测。这些数据可能会为监测处于 MCI 风险中的个人所做的工作分配提供信息。037)在非西班牙裔中,而身体行为评分是西班牙裔中最具预测性的 MCI(HR = 2.55,p = 0.029)。在西班牙裔中,情感情绪因素的高分也倾向于增加 MCI 的风险(HR = 2.09,p = 0.06)。西班牙裔和非西班牙裔白人的 NPS 亚型对从正常认知到 MCI 的进展进行了不同的预测。这些数据可能会为监测处于 MCI 风险中的个人所做的工作分配提供信息。037)在非西班牙裔中,而身体行为评分是西班牙裔中最具预测性的 MCI(HR = 2.55,p = 0.029)。在西班牙裔中,情感情绪因素的高分也倾向于增加 MCI 的风险(HR = 2.09,p = 0.06)。西班牙裔和非西班牙裔白人的 NPS 亚型对从正常认知到 MCI 的进展进行了不同的预测。这些数据可能会为监测处于 MCI 风险中的个人所做的工作分配提供信息。

更新日期:2020-09-11
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