Controlled Nutrient Delivery to Pancreatic Islets Using Polydopamine-Coated Mesoporous Silica Nanoparticles.,Nano Letters

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Controlled Nutrient Delivery to Pancreatic Islets Using Polydopamine-Coated Mesoporous Silica Nanoparticles.
Nano Letters ( IF 9.6 ) Pub Date : 2020-09-10 , DOI: 10.1021/acs.nanolett.0c02576
Mehdi Razavi _{1,

2,

3} , Rosita Primavera ₁ , Bhavesh D Kevadiya ₁ , Jing Wang ₁ , Mujib Ullah ₁ , Peter Buchwald ₄ , Avnesh S Thakor ₁

Affiliation

In the present study, we created a nanoscale platform that can deliver nutrients to pancreatic islets in a controlled manner. Our platform consists of a mesoporous silica nanoparticle (MSNP), which can be loaded with glutamine (G: an essential amino acid required for islet survival and function). To control the release of G, MSNPs were coated with a polydopamine (PD) layer. With the optimal parameters (0.5 mg/mL and 0.5 h), MSNPs were coated with a layer of PD, which resulted in a delay of G release from MSNPs over 14 d (57.4 ± 4.7% release). Following syngeneic renal subcapsule islet transplantation in diabetic mice, PDG-MSNPs improved the engraftment of islets (i.e., enhanced revascularization and reduced inflammation) as well as their function, resulting in re-establishment of glycemic control. Collectively, our data show that PDG-MSNPs can support transplanted islets by providing them with a controlled and sustained supply of nutrients.

中文翻译：

使用聚多巴胺涂覆的介孔二氧化硅纳米颗粒控制营养物输送至胰岛。

在本研究中，我们创建了一个纳米级平台，可以以受控方式将营养物质输送到胰岛。我们的平台由介孔二氧化硅纳米颗粒（MSNP）组成，可以负载谷氨酰胺（G：胰岛生存和功能所需的必需氨基酸）。为了控制 G 的释放，MSNP 涂有聚多巴胺 (PD) 层。在最佳参数（0.5 mg/mL 和 0.5 h）下，MSNP 被一层 PD 包被，导致 MSNP 的 G 释放延迟超过 14 d（57.4 ± 4.7% 释放）。在糖尿病小鼠中进行同基因肾囊下胰岛移植后，PDG-MSNP 改善了胰岛的植入（即增强血运重建和减少炎症）及其功能，从而重新建立血糖控制。总的来说，我们的数据表明，PDG-MSNP 可以通过为移植的胰岛提供受控和持续的营养供应来支持移植的胰岛。

更新日期：2020-10-15

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