Currently, dengue control relies largely on reactive vector control programmes. Proactive vector-control using a rational, well-balanced integrated vector management approach may prove more successful for dengue control. As part of the development of a cluster randomized controlled epidemiological trial, a study was conducted in Johor Bahru, Malaysia. The study included one control site (three buildings) and three intervention sites which were treated as follows: targeted outdoor residual spraying only (TORS site, two buildings); deployment of autodissemination devices only (ADD site, four buildings); and the previous two treatments combined (TORS + ADD site, three buildings). The primary entomological measurement was per cent of positive ovitraps—ovitrap index (OI). The effect of each intervention on OI was analyzed by a modified ordinary least squares regression model. Relative to the control site, the TORS and ADD sites showed a reduction in the Aedes OI (−6.5%, P = 0.04 and −8.3%, P = 0.10, respectively). Analysis by species showed that, relative to control, the Ae. aegypti OI was lower in ADD (−8.9%, P = 0.03) and in TORS (−10.4%, P = 0.02). No such effect was evident in the TORS + ADD site. The present study provides insights into the methods to be used for the main trial. The combination of multiple insecticides with different modes of action in one package is innovative, although we could not demonstrate the additive effect of TORS + ADD. Further work is required to strengthen our understanding of how these interventions impact dengue vector populations and dengue transmission.

当前，登革热控制主要依靠反应性媒介控制程序。使用合理，均衡的综合病媒管理方法进行主动病媒控制可能对登革热控制更为成功。作为整群随机对照流行病学试验的一部分，在马来西亚新山进行了一项研究。该研究包括一个控制点（三座建筑物）和三个干预点，分别进行如下处理：仅针对性地进行室外残留喷涂（TORS地点，两座建筑物）；仅部署自动分发设备（ADD站点，四栋建筑物）；和之前的两种处理方法结合在一起（TORS + ADD站点，三栋建筑物）。主要的昆虫学测量为阳性产卵器的百分比-产卵器指数（OI）。通过修改的普通最小二乘回归模型分析了每种干预对OI的影响。相对于对照位点，TORS和ADD位点显示伊蚊（Iedes OI）（分别为-6.5％，P = 0.04和-8.3％，P = 0.10）。按物种分析表明，相对于对照而言，Ae。埃及OI在ADD（-8.9％，P = 0.03）和TORS（-10.4％，P = 0.02）中较低。在TORS + ADD网站中没有明显的影响。本研究提供了对用于主要试验的方法的见解。尽管我们无法证明TORS + ADD的累加作用，但在一个包装中将多种具有不同作用方式的杀虫剂组合使用是一种创新。需要进一步的工作来加深我们对这些干预措施如何影响登革热媒介种群和登革热传播的理解。