Species have definitive genomes. Even so, the transcriptional and translational products of the genome are dynamic and subject to change over time. This is especially true for the proteins secreted by ticks at the tick-host feeding interface that represent a complex system known as the sialoverse. The sialoverse represent all of the proteins derived from tick salivary glands for all tick species that may be involved in tick-host interaction and the modulation of the host's defense mechanisms. The current study contemplates the advances made over time to understand and describe the complexity present in the sialoverse. Technological advances at given periods in time allowed detection of functions, genes, and proteins enabling a deeper insight into the complexity of the sialoverse and a concomitant expansion in complexity with as yet, no end in sight. The importance of systematic classification of the sialoverse is highlighted with the realization that our coverage of transcriptome and proteome space remains incomplete, but that complete descriptions may be possible in the future. Even so, analysis and integration of the sialoverse into a comprehensive understanding of tick-host interactions may require further technological advances given the high level of expected complexity that remains to be uncovered.

物种具有确定的基因组。即使这样，基因组的转录和翻译产物还是动态的，并且会随着时间而变化。对于由tick-宿主进食界面上的s分泌的蛋白质而言，尤其如此，它代表了被称为唾液腺的复杂系统。唾液腺代表所有可能与tick-宿主相互作用和宿主防御机制的调节有关的所有tick物种的唾液腺分泌的所有蛋白质。当前的研究考虑了随着时间的推移在理解和描述唾液腺中存在的复杂性方面所取得的进步。在给定的时间段内，技术的进步允许对功能，基因和蛋白质的检测，从而可以更深入地了解唾液腺的复杂性，以及随之而来的复杂性的扩展，没有尽头。意识到我们对转录组和蛋白质组空间的覆盖仍然不完整，但是对唾液腺进行系统分类的重要性得到了强调，但将来可能会进行完整的描述。即使如此，鉴于仍然需要发现很高的预期复杂性，将唾液腺的分析和整合到对壁虱-宿主相互作用的全面理解中可能还需要进一步的技术进步。