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Enhancing antibacterial performance and biocompatibility of pure titanium by a two-step electrochemical surface coating.
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2020-09-11 , DOI: 10.1021/acsami.0c10032 Sen Yu 1, 2 , Dagang Guo 1 , Jianye Han 2 , Lijuan Sun 1 , Hui Zhu 1 , Zhentao Yu 2 , Matthew Dargusch 3 , Gui Wang 3
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2020-09-11 , DOI: 10.1021/acsami.0c10032 Sen Yu 1, 2 , Dagang Guo 1 , Jianye Han 2 , Lijuan Sun 1 , Hui Zhu 1 , Zhentao Yu 2 , Matthew Dargusch 3 , Gui Wang 3
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A two-step electrochemical surface treatment has been developed to modify the CP Ti surface on commercially pure titanium grade 2 (CP Ti): (1) anodic oxidation to form TiO2 nanotube precoatings loaded with silver (Ag) and (2) microarc oxidation (MAO) to produce a porous Ca-P-Ag coating in an electrolyte containing Ag, Ca, and P. One-step MAO in the same electrolyte has also been used to produce porous Ca-P-Ag coatings without anodic oxidation and preloaded Ag as a control. Surface morphologies and alloying chemistry of the two coatings were characterized by SEM, EDS, and XPS. Biocompatibility and antimicrobial properties have been evaluated by the MTT method and co-culture of Staphylococcus aureus, respectively. It is demonstrated that porous coatings with high Ag content can be achieved on the CP Ti by the two-step treatment. The optimized MAO voltage for excellent comprehensive properties of the coating is 350 V, in which a suitable chemical equilibrium between Ag, Ca, and P contents and a Ca/P ratio of 1.67 similar to HA can be obtained, and the Ag particles are in the size of less than 100 nm and embedded into the underneath of the coating surface. After being contacted with S. aureus for 1 and 7 days, the average bactericidal rates were 99.53 and 89.27% and no cytotoxicity was detected. In comparison, the one-step MAO coatings contained less Ag, had a lower Ca/P ratio, and showed lower antimicrobial ability than the two-step treated samples.
中文翻译：
通过两步电化学表面涂层增强纯钛的抗菌性能和生物相容性。
已经开发了两步电化学表面处理来修饰商用纯钛2级（CP Ti）上的CP Ti表面：（1）阳极氧化形成负载有银（Ag）的TiO 2纳米管预涂层和（2）微弧氧化（MAO）可在包含Ag，Ca和P的电解质中生产多孔Ca-P-Ag涂层。同一电解质中的一步MAO也已用于生产没有阳极氧化和预载的多孔Ca-P-Ag涂层以银为对照。通过SEM，EDS和XPS对两种涂层的表面形貌和合金化化学特性进行了表征。已通过MTT方法和金黄色葡萄球菌共培养评估了生物相容性和抗菌性能， 分别。已经证明，通过两步处理可以在CP Ti上获得具有高Ag含量的多孔涂层。为了获得优异的涂层综合性能，优化的MAO电压为350 V，其中，Ag，Ca和P含量之间的化学平衡合适，Ca / P比值类似于HA，为1.67，并且Ag颗粒处于尺寸小于100 nm，并嵌入涂层表面的下面。与金黄色葡萄球菌接触1天和7天后，平均杀菌率分别为99.53和89.27％，并且未检测到细胞毒性。相比之下，一步法MAO涂层与两步法处理的样品相比，包含的Ag较少，Ca / P比较低，并且显示出较低的抗菌能力。
更新日期：2020-10-07
中文翻译：
通过两步电化学表面涂层增强纯钛的抗菌性能和生物相容性。
已经开发了两步电化学表面处理来修饰商用纯钛2级（CP Ti）上的CP Ti表面：（1）阳极氧化形成负载有银（Ag）的TiO 2纳米管预涂层和（2）微弧氧化（MAO）可在包含Ag，Ca和P的电解质中生产多孔Ca-P-Ag涂层。同一电解质中的一步MAO也已用于生产没有阳极氧化和预载的多孔Ca-P-Ag涂层以银为对照。通过SEM，EDS和XPS对两种涂层的表面形貌和合金化化学特性进行了表征。已通过MTT方法和金黄色葡萄球菌共培养评估了生物相容性和抗菌性能， 分别。已经证明，通过两步处理可以在CP Ti上获得具有高Ag含量的多孔涂层。为了获得优异的涂层综合性能，优化的MAO电压为350 V，其中，Ag，Ca和P含量之间的化学平衡合适，Ca / P比值类似于HA，为1.67，并且Ag颗粒处于尺寸小于100 nm，并嵌入涂层表面的下面。与金黄色葡萄球菌接触1天和7天后，平均杀菌率分别为99.53和89.27％，并且未检测到细胞毒性。相比之下，一步法MAO涂层与两步法处理的样品相比，包含的Ag较少，Ca / P比较低，并且显示出较低的抗菌能力。
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