Protein misfolding and aggregation have attracted immense research interests due to their connection with an array of degenerative diseases including neurodegenerative disorders and non-neuropathic diseases. Inhibition or diminution of the formation of protein aggregates is considered as a potential therapeutic strategy to cure these debilitating maladies. A large number of compounds including flavonoids, surfactants, osmolytes, vitamins, nanoparticles, etc. have been explored for impeding protein aggregation process and ameliorating neurodegenerative disorders. Even though a plethora of strategies have been designed to suppress protein aggregation, the final success rate is limited due to the lack of in-depth understanding of the aggregation pathway. In this context, polymeric materials are attracting the attention of researchers owing to their multifarious applications in the field of biomedical science and technology, and their unique properties as many parameters like functionality, molecular weight, architecture, etc. can be easily manipulated to improve their efficacy as well as meet clinical requirements. This review article highlights an outline of protein misfolding and aggregation, their mechanistic pathway, the factors responsible for aggregation, and potential therapeutic strategies for the intervention of those debilitating pathological conditions. Especially, the primary focus of this review article is to delineate the obligatory role of polymeric materials on protein aggregation pathway and encourage researchers to fabricate effective polymeric materials for designing next generation antiamyloidogenic therapeutic agents.

中文翻译：

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合成聚合物对淀粉样蛋白原纤维化的调节：神经退行性疾病背景下的最新进展

蛋白质错误折叠和聚集因其与一系列退行性疾病（包括神经退行性疾病和非神经病性疾病）的联系而引起了巨大的研究兴趣。抑制或减少蛋白质聚集体的形成被认为是治愈这些使人衰弱的疾病的潜在治疗策略。已经探索了大量化合物，包括黄酮类化合物、表面活性剂、渗透剂、维生素、纳米粒子等，用于阻止蛋白质聚集过程和改善神经退行性疾病。尽管已经设计了过多的策略来抑制蛋白质聚集，但由于缺乏对聚集途径的深入了解，最终成功率有限。在这种情况下，高分子材料因其在生物医学科学和技术领域的广泛应用而受到研究人员的关注，其独特的性能，如功能、分子量、结构等许多参数可以很容易地操纵以提高其功效以及满足临床要求。这篇综述文章重点介绍了蛋白质错误折叠和聚集的概述、它们的机制途径、导致聚集的因素以及干预这些使人衰弱的病理状况的潜在治疗策略。尤其，