ABSTRACT

A new porous 3D coordination polymer (CP), namely [Mn₂(Htpim)₂(odpa)]·8H₂O (1, Htpim = 2,4,5-tri(4-pyridyl)-imidazole, odpa = 4,4′-oxydiphthalate), was successfully synthesized. Furthermore, complex 1 could be applied as a probe displaying good ion sensing property of Cr³⁺ ion by fluorescence quenching. For the treatment of the temporary osteoporosis of the hip (TOH), the biological function of the compound was evaluated. Annexin V-FITC/PI assay was performed to measure the bone marrow stem cells’ apoptosis after compound treatment. Besides, western blot was utilized to determine the signaling pathway of the wnt/β-catenin activation in bone marrow stem cells.

摘要

一种新型多孔3D配位聚合物（CP），即[Mn ₂ (Htpim) ₂ (odpa)]·8H ₂ O (1, Htpim = 2,4,5-tri(4-pyridyl)-imidazole, odpa = 4, 4'-oxydiphthalate), 成功合成。此外，配合物1可用作探针， 通过荧光猝灭显示出对Cr ^{3+离子的良好离子感应特性。}对于髋关节暂时性骨质疏松症 (TOH) 的治疗，评估了该化合物的生物学功能。采用Annexin V-FITC/PI法测定复合处理后骨髓干细胞的凋亡情况。此外，利用蛋白质印迹确定了骨髓干细胞中wnt/β-catenin激活的信号通路。