ABSTRACT

The aim of this study was to evaluate the predictive value of the anti-Mullerian hormone (AMH) level for early pregnancy loss and to compare the significance of AMH level to age as prognostic factors of pregnancy loss in subfertile women. The outcome of 848 subfertile patients confirmed with intrauterine pregnancies by ultrasound within 1 year of measuring serum AMH level were retrospectively analyzed. Among 848 patients, 206 women were diagnosed with early pregnancy loss. The mean age of the 848 patients was 35.66 ± 3.61 years (range: 26–46 years), and the mean AMH level was 2.95 ± 1.89 (range: 0.14–8.82 ng/mL). There were no significant differences in gravidity, parity, body mass index (BMI), and previous abortion history depending on early pregnancy loss. However, multivariable logistic regression analysis confirmed that the probability of early pregnancy loss is significantly affected by age (odd ratio, 1.079: 1.025–1.135, P = 0.004) and AMH (odd ratio, 0.885: 0.797–0.982, p = 0.022). According to this study, AMH level and age are both powerful predictors of early pregnancy loss. While chronological age is already well known as a factor related to early pregnancy loss, AMH was also considered when individualizing risk prediction for early pregnancy loss.

摘要

本研究的目的是评估抗苗勒管激素 (AMH) 水平对早期流产的预测价值，并比较 AMH 水平与年龄作为不育女性流产预后因素的显着性。回顾性分析了 848 例在测量血清 AMH 水平后 1 年内经超声证实为宫内妊娠的低生育力患者的结局。在 848 名患者中，206 名女性被诊断为早期流产。848 名患者的平均年龄为 35.66 ± 3.61 岁（范围：26-46 岁），平均 AMH 水平为 2.95 ± 1.89（范围：0.14-8.82 ng/mL）。根据早期妊娠丢失，在妊娠、产次、体重指数 (BMI) 和既往流产史方面没有显着差异。然而，多变量logistic回归分析证实，早期流产概率受年龄（奇数比，1.079：1.025-1.135，P=0.004）和AMH（奇数比，0.885：0.797-0.982，p=0.022）影响显着。根据这项研究，AMH 水平和年龄都是早期流产的有力预测因素。虽然实足年龄已经是众所周知的与早期流产相关的因素，但在对早期流产进行个体化风险预测时也考虑了 AMH。