Alcohol drinking may be associated with an increased risk of various metabolic diseases. Rat lines selectively bred for alcohol preference and alcohol avoidance constitute an interesting model to study inherited factors related to alcohol drinking and metabolic disorders. The aim of the present study was to compare the levels of selected laboratory biomarkers of metabolic disorders in blood samples from naïve offspring of Warsaw alcohol high-preferring (WHP), Warsaw alcohol low-preferring (WLP), and wild Wistar rats. Blood samples were collected from 3-month old (300–350 g) alcohol-naïve, male offspring of WHP (n = 8) and WLP rats (n = 8), as well as alcohol-naïve, male, wild Wistar rats. Markers of metabolic, hepatic, and pancreatic disorders were analysed (levels of homocysteine, glucose, total cholesterol, triglycerides and γ-glutamyl transferase (GGT), aspartate (AST), alanine aminotransferase (ALT), and amylase serum activities). Alcohol-naïve offspring of WHP, WLP, and wild Wistar rats differed significantly in the levels of triglycerides, total cholesterol, homocysteine, as well as in the activity of GGT, ALT, AST, and amylase enzymes. Most markers in the alcohol-naïve offspring of WHP rats were altered even thought they were never exposed to alcohol pre- or postnatally. This may suggest that parental alcohol abuse can have a detrimental influence on offspring vulnerability to metabolic disorders.

中文翻译：

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酒精摄入的代际影响：未饮酒大鼠后代的代谢紊乱

饮酒可能与各种代谢疾病的风险增加有关。为酒精偏好和酒精避免而选择性繁殖的大鼠品系构成了一个有趣的模型，用于研究与饮酒和代谢紊乱相关的遗传因素。本研究的目的是比较华沙酒精高偏好 (WHP)、华沙酒精低偏好 (WLP) 和野生 Wistar 大鼠幼稚后代血液样本中选定的代谢紊乱实验室生物标志物的水平。从 WHP（n = 8）和 WLP 大鼠（n = 8）的 3 个月大（300–350 g）未饮酒的雄性后代以及未饮酒的雄性野生 Wistar 大鼠收集血液样本。分析了代谢、肝脏和胰腺疾病的标志物（同型半胱氨酸、葡萄糖、总胆固醇、甘油三酯和 γ-谷氨酰转移酶 (GGT)、天冬氨酸 (AST)、丙氨酸转氨酶 (ALT) 和淀粉酶血清活性)。WHP、WLP 和野生 Wistar 大鼠的未饮酒后代在甘油三酯、总胆固醇、同型半胱氨酸的水平以及 GGT、ALT、AST 和淀粉酶的活性方面存在显着差异。WHP 大鼠从未接触过酒精的后代中的大多数标记都发生了改变，即使它们在出生前或出生后从未接触过酒精。这可能表明，父母酗酒会对后代易患代谢紊乱产生不利影响。以及 GGT、ALT、AST 和淀粉酶的活性。WHP 大鼠从未接触过酒精的后代中的大多数标记都发生了改变，即使它们在出生前或出生后从未接触过酒精。这可能表明，父母酗酒会对后代易患代谢紊乱产生不利影响。以及 GGT、ALT、AST 和淀粉酶的活性。WHP 大鼠从未接触过酒精的后代中的大多数标记都发生了改变，即使它们在出生前或出生后从未接触过酒精。这可能表明，父母酗酒会对后代易患代谢紊乱产生不利影响。