Gating and regulation of the calcium release‐activated calcium channel: Recent progress from experiments and molecular modeling,Biopolymers

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Gating and regulation of the calcium release‐activated calcium channel: Recent progress from experiments and molecular modeling
Biopolymers ( IF 3.2 ) Pub Date : 2020-09-10 , DOI: 10.1002/bip.23392
Jun Huo ₁ , Hao Dong _{1,

2}

Affiliation

Calcium release‐activated calcium (CRAC) channels are highly calcium ion (Ca2+)‐selective channels in the plasma membrane. The transient drop of endoplasmic reticulum Ca2+ level activates its calcium sensor stromal interaction molecule (STIM) and then triggers the gating of the CRAC channel pore unit Orai. This process involves a variety of activities of the immune system. Therefore, understanding how the activation and regulation of the CRAC channel can be accomplished is essential. Here we briefly summarize the recent progress on Orai gating and its regulation by 2‐aminoethoxydiphenylborate (2‐APB) obtained from structural biology studies, biochemical and electrophysiological measurements, as well as molecular modeling. Indeed, integration between experiments and computations has further deepened our understanding of the channel gating and regulation.

中文翻译：

钙释放激活钙通道的门控和调节：实验和分子建模的最新进展

钙释放激活钙 (CRAC) 通道是质膜中的高度钙离子 (Ca2+) 选择性通道。内质网 Ca2+ 水平的瞬时下降激活其钙传感器基质相互作用分子 (STIM)，然后触发 CRAC 通道孔单元 Orai 的门控。这个过程涉及免疫系统的各种活动。因此，了解如何激活和调节 CRAC 通道至关重要。在这里，我们简要总结了从结构生物学研究、生化和电生理测量以及分子建模中获得的 2-氨基乙氧基二苯基硼酸盐 (2-APB) 对 Orai 门控及其调控的最新进展。的确，

更新日期：2020-09-10

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