Recent progress in study of circRNAs and its role in leukemia,Journal of Leukocyte Biology

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Recent progress in study of circRNAs and its role in leukemia
Journal of Leukocyte Biology ( IF 3.6 ) Pub Date : 2020-09-10 , DOI: 10.1002/jlb.2ru0619-213r
Lei Fu _{1,

2} , Doudou Tang ₃ , Ailian Sun ₁ , Dengqin Zhu ₁ , Guangsen Zhang _{1,

2} , Yewei Wang _{1,

2}

Affiliation

Circular RNAs (circRNAs) are a class of newly identified noncoding RNA and are considered as a new feature of eukaryotic gene expression. Hundreds of thousands of endogenous circRNAs have been found in mammalian cells, which we knew little before. CircRNAs are covalently closed, circular RNA molecules that typically comprise exonic sequences and are spliced at canonical splice sites. Researchers with RNA‐Seq technology have identified that the expression of circRNAs is developmentally regulated, tissue‐ and cell‐type specific. Like long noncoding RNAs (lncRNAs), circRNAs are becoming a new research hotspot in the RNA field, and aberrant expression of circRNAs could contribute to carcinogenesis. Recent studies have demonstrated that circRNAs play important roles in the development, maintenance, and progression of leukemia. Herein, we describe the biologic characteristics and functions of circRNAs, with a focus on circRNAs that play essential roles in leukemia.

中文翻译：

circRNA的研究及其在白血病中的作用的最新进展

环状RNA（circRNA）是一类新近鉴定的非编码RNA，被认为是真核基因表达的新特征。在哺乳动物细胞中发现了成千上万种内源性circRNA，这是我们鲜为人知的。CircRNA是共价闭合的环状RNA分子，通常包含外显子序列，并在规范剪接位点剪接。使用RNA‐Seq技术的研究人员已经确定，circRNA的表达受到发育调节，组织和细胞类型的特异性。像长非编码RNA（lncRNA）一样，circRNA成为RNA领域的一个新研究热点，而circRNA的异常表达可能会促进癌变。最近的研究表明，circRNA在白血病的发生，维持和进展中起着重要作用。在此处，

更新日期：2020-09-10

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