CHK1 monitors spindle assembly checkpoint and DNA damage repair during the first cleavage of mouse early embryos,Cell Proliferation

当前位置： X-MOL 学术 › Cell Prolif. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

CHK1 monitors spindle assembly checkpoint and DNA damage repair during the first cleavage of mouse early embryos
Cell Proliferation ( IF 5.9 ) Pub Date : 2020-09-10 , DOI: 10.1111/cpr.12895
Jia-Qian Ju ₁ , Xiao-Han Li ₁ , Meng-Hao Pan ₁ , Yao Xu ₁ , Ming-Hong Sun ₁ , Yi Xu ₁ , Shao-Chen Sun ₁

Affiliation

DNA damage and errors of accurate chromosome segregation lead to aneuploidy and foetal defects. DNA repair and the spindle assembly checkpoint (SAC) are the mechanisms developed to protect from these defects. Checkpoint kinase 1 (CHK1) is reported to be an important DNA damage response protein in multiple models, but its functions remain unclear in early mouse embryos.

中文翻译：

CHK1 在小鼠早期胚胎的第一次分裂过程中监测纺锤体组装检查点和 DNA 损伤修复

DNA 损伤和准确的染色体分离错误导致非整倍体和胎儿缺陷。DNA 修复和纺锤体组装检查点 (SAC) 是为防止这些缺陷而开发的机制。据报道，检查点激酶 1 (CHK1) 在多种模型中是一种重要的 DNA 损伤反应蛋白，但其在早期小鼠胚胎中的功能仍不清楚。

更新日期：2020-09-10

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11