Bioresorbable and degradable behaviors of PGA: Current state and future prospects,Polymer Engineering and Science

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Bioresorbable and degradable behaviors of PGA: Current state and future prospects
Polymer Engineering and Science ( IF 3.2 ) Pub Date : 2020-09-10 , DOI: 10.1002/pen.25508
Yan Jie Low _{1,

2} , Andri Andriyana _{1,

2} , Bee Chin Ang _{1,

3} , Nor Ishida Zainal Abidin _{1,

2}

Affiliation

Polyglycolic acid (PGA) is a class of semicrystalline, bioresorbable polymers that have been widely used in a number of applications. No other bioresorbable materials can fully replace PGA in tissue engineering. Understanding degradation mechanisms in PGA is important for improving the efficiency and effectiveness in various fields including implantation. This review begins with a discussion on terminology of polymer degradation and hydrolytic degradation mechanism with a delineative model. This review also focus on previous degradation studies taking advantage of its fast‐degrading behavior and the mechanism behind hexafluoroisopropanol (HFIP) being the sole solvent for PGA. Finally, the merits of PGA are discussed with many potential future applications along with their associated challenges.

中文翻译：

PGA的生物可吸收和降解行为：现状和未来展望

聚乙醇酸（PGA）是一类半结晶，可生物吸收的聚合物，已广泛用于许多应用中。在组织工程中，没有其他生物可吸收材料可以完全替代PGA。了解PGA中的降解机制对于提高包括植入在内的各个领域的效率和有效性至关重要。这篇综述首先讨论了具有描述性模型的聚合物降解和水解降解机理的术语。这篇综述还着眼于先前的降解研究，利用了其快速降解的特性以及六氟异丙醇（HFIP）成为PGA唯一溶剂的机理。最后，讨论了PGA的优点以及许多潜在的未来应用以及相关的挑战。

更新日期：2020-11-12

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