Common and separable neural alterations in substance use disorders: A coordinate-based meta-analyses of functional neuroimaging studies in humans.,Human Brain Mapping

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Common and separable neural alterations in substance use disorders: A coordinate-based meta-analyses of functional neuroimaging studies in humans.
Human Brain Mapping ( IF 3.5 ) Pub Date : 2020-09-10 , DOI: 10.1002/hbm.25085
Benjamin Klugah-Brown ₁ , Xin Di ₂ , Jana Zweerings _{3,

4} , Klaus Mathiak _{3,

4} , Benjamin Becker ₁ , Bharat Biswal _{1,

2}

Affiliation

Delineating common and separable neural alterations in substance use disorders (SUD) is imperative to understand the neurobiological basis of the addictive process and to inform substance‐specific treatment strategies. Given numerous functional MRI (fMRI) studies in different SUDs, a meta‐analysis could provide an opportunity to determine robust shared and substance‐specific alterations. The present study employed a coordinate‐based meta‐analysis covering fMRI studies in individuals with addictive cocaine, cannabis, alcohol, and nicotine use. The primary meta‐analysis demonstrated common alterations in primary dorsal striatal, and frontal circuits engaged in reward/salience processing, habit formation, and executive control across different substances and task‐paradigms. Subsequent sub‐analyses revealed substance‐specific alterations in frontal and limbic regions, with marked frontal and insula‐thalamic alterations in alcohol and nicotine use disorders respectively. Examining task‐specific alterations across substances revealed pronounced frontal alterations during cognitive processes yet stronger striatal alterations during reward‐related processes. Finally, an exploratory meta‐analysis revealed that neurofunctional alterations in striatal and frontal reward processing regions can already be determined with a high probability in studies with subjects with comparably short durations of use. Together the findings emphasize the role of dysregulations in frontostriatal circuits and dissociable contributions of these systems in the domains of reward‐related and cognitive processes which may contribute to substance‐specific behavioral alterations.

中文翻译：

物质使用障碍中常见和可分离的神经改变：基于坐标的人类功能神经影像学研究荟萃分析。

描述物质使用障碍 (SUD) 中常见和可分离的神经改变对于了解成瘾过程的神经生物学基础并为特定物质的治疗策略提供信息至关重要。鉴于在不同 SUD 中进行了大量功能性 MRI (fMRI) 研究，荟萃分析可以提供一个机会来确定强大的共享和物质特异性改变。本研究采用了基于坐标的荟萃分析，涵盖了对可卡因、大麻、酒精和尼古丁使用成瘾的个体的 fMRI 研究。主要的荟萃分析证明了初级背侧纹状体和额叶回路的常见改变，参与奖励/显着性处理、习惯形成和不同物质和任务范式的执行控制。随后的亚组分析揭示了额叶和边缘区域的物质特异性改变，酒精和尼古丁使用障碍分别具有明显的额叶和脑岛-丘脑改变。检查跨物质的特定任务改变揭示了认知过程中明显的额叶改变，但在奖励相关过程中纹状体改变更强烈。最后，一项探索性荟萃分析表明，在对使用时间相对较短的受试者的研究中，纹状体和额叶奖励处理区域的神经功能改变已经很有可能被确定。

更新日期：2020-10-14

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