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Intrinsic Heart Regeneration in Adult Vertebrates May be Strictly Limited to Low-Metabolic Ectotherms.
BioEssays ( IF 3.2 ) Pub Date : 2020-09-11 , DOI: 10.1002/bies.202000054 Anita Dittrich 1 , Kasper Hansen 1, 2, 3, 4 , Mette Irene Theilgaard Simonsen 5 , Morten Busk 6, 7 , Aage Kristian Olsen Alstrup 5 , Henrik Lauridsen 1
BioEssays ( IF 3.2 ) Pub Date : 2020-09-11 , DOI: 10.1002/bies.202000054 Anita Dittrich 1 , Kasper Hansen 1, 2, 3, 4 , Mette Irene Theilgaard Simonsen 5 , Morten Busk 6, 7 , Aage Kristian Olsen Alstrup 5 , Henrik Lauridsen 1
Affiliation
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The heart has a high‐metabolic rate, and its “around‐the‐clock” vital role to sustain life sets it apart in a regenerative setting from other organs and appendages. The landscape of vertebrate species known to perform intrinsic heart regeneration is strongly biased toward ectotherms—for example, fish, salamanders, and embryonic/neonatal ectothermic mammals. It is hypothesized that intrinsic heart regeneration is exclusively limited to the low‐metabolic hearts of ectotherms. The biomedical field of regenerative medicine seeks to devise biologically inspired regenerative therapies to diseased human hearts. Falsification of the ectothermy dependency for heart regeneration hypothesis may be a crucial prerequisite to meaningfully seek inspiration in established ectothermic regenerative animal models. Otherwise, engineering approaches to construct artificial heart components may constitute a more viable path toward regenerative therapies. A more strict definition of regenerative phenomena is generated and several testable sub‐hypotheses and experimental avenues are put forward to elucidate the link between heart regeneration and metabolism. Also see the video abstract here https://youtu.be/fZcanaOT5z8.
中文翻译：
成年脊椎动物的内在心脏再生可能严格限于低代谢的外温动物。
心脏具有高代谢率，其“全天候”维持生命的重要作用使其在再生环境中与其他器官和附件区分开来。已知执行内在心脏再生的脊椎动物物种的景观强烈偏向于变温动物——例如，鱼、蝾螈和胚胎/新生儿变温哺乳动物。据推测，内在心脏再生仅限于外温动物的低代谢心脏。再生医学的生物医学领域寻求设计受生物学启发的再生疗法来治疗患病的人类心脏。对心脏再生假设的变温依赖性的证伪可能是在已建立的变温再生动物模型中有意义地寻求灵感的关键先决条件。否则，构建人工心脏组件的工程方法可能构成一条更可行的再生疗法途径。再生现象产生了更严格的定义，并提出了几个可测试的子假设和实验途径来阐明心脏再生和新陈代谢之间的联系。另请参阅此处的视频摘要 https://youtu.be/fZcanaOT5z8。
更新日期：2020-10-22
中文翻译：
成年脊椎动物的内在心脏再生可能严格限于低代谢的外温动物。
心脏具有高代谢率，其“全天候”维持生命的重要作用使其在再生环境中与其他器官和附件区分开来。已知执行内在心脏再生的脊椎动物物种的景观强烈偏向于变温动物——例如，鱼、蝾螈和胚胎/新生儿变温哺乳动物。据推测，内在心脏再生仅限于外温动物的低代谢心脏。再生医学的生物医学领域寻求设计受生物学启发的再生疗法来治疗患病的人类心脏。对心脏再生假设的变温依赖性的证伪可能是在已建立的变温再生动物模型中有意义地寻求灵感的关键先决条件。否则，构建人工心脏组件的工程方法可能构成一条更可行的再生疗法途径。再生现象产生了更严格的定义，并提出了几个可测试的子假设和实验途径来阐明心脏再生和新陈代谢之间的联系。另请参阅此处的视频摘要 https://youtu.be/fZcanaOT5z8。
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