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Metal‐Free Decarboxylation of Alkynoic Acids for the Synthesis of Terminal Alkynes
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2020-09-11 , DOI: 10.1002/ajoc.202000363 Eunkyeong Seo 1 , Jonghoon Oh 1 , Sunwoo Lee 2
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2020-09-11 , DOI: 10.1002/ajoc.202000363 Eunkyeong Seo 1 , Jonghoon Oh 1 , Sunwoo Lee 2
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Terminal alkynes were readily obtained via the reaction of alkynoic acids with N,N,N’,N’‐teramethylethylenediamine (TMEDA) in DMSO at 65 °C for 12 h. This method gave good yields and showed high functional group tolerance. In addition, deuterated terminal alkynes were formed in good yields when alkynoic acids were treated with D2O prior to the reaction with TMEDA.
中文翻译：
炔酸的无金属脱羧用于末端炔烃的合成
炔烃与N，N，N'，N'-四甲基乙二胺（TMEDA）在DMSO中于65°C反应12 h即可轻松获得末端炔烃。该方法具有良好的收率并显示出高的官能团耐受性。另外，当在与TMEDA反应之前用D 2 O处理炔酸时，以良好的产率形成氘代末端炔。
更新日期：2020-11-17
中文翻译：
炔酸的无金属脱羧用于末端炔烃的合成
炔烃与N，N，N'，N'-四甲基乙二胺（TMEDA）在DMSO中于65°C反应12 h即可轻松获得末端炔烃。该方法具有良好的收率并显示出高的官能团耐受性。另外，当在与TMEDA反应之前用D 2 O处理炔酸时，以良好的产率形成氘代末端炔。
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