Supramolecular Catalysis of the Pictet-Spengler Reaction with an Endohedrally Functionalized Self-Assembled Cage Complex.,Angewandte Chemie International Edition

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Supramolecular Catalysis of the Pictet-Spengler Reaction with an Endohedrally Functionalized Self-Assembled Cage Complex.
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2020-09-11 , DOI: 10.1002/anie.202009553
Courtney Ngai ₁ , Colomba M Sanchez-Marsetti ₁ , W Hill Harman ₁ , Richard J Hooley ₁

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An endohedrally functionalized self‐assembled Fe₄L₆ cage complex can catalyze oxa‐Pictet—Spengler cyclizations of tryptophols and various aldehyde derivatives, showing strong rate accelerations and size‐selectivity. Selective molecular recognition of substrates controls the reactivity, and the cage is capable of binding and activating multiple different species along the multistep reaction pathway. The combination of a functionalized active site, size‐selective reactivity, and multistep activation, all from a single host molecule, illustrates the biomimetic nature of the catalysis.

中文翻译：

Pictet-Spengler反应的超分子催化与内表面官能化的自组装笼复合物。

内膜功能化的自组装Fe ₄ L ₆笼状复合物可以催化色酚和各种醛衍生物的Oxa-Pictet-Spengler环化反应，显示出较强的速率加速和尺寸选择性。底物的选择性分子识别控制反应性，并且笼子能够沿着多步反应路径结合并激活多个不同的物种。来自单个宿主分子的功能化活性位点，大小选择性反应性和多步激活的组合说明了催化的仿生性质。

更新日期：2020-09-11

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