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Anticancer and antioxidant efficacy of silver nanoparticles synthesized from fruit of Morinda citrifolia Linn on Ehrlich ascites carcinoma mice
Journal of King Saud University-Science ( IF 3.7 ) Pub Date : 2020-09-11 , DOI: 10.1016/j.jksus.2020.09.005
Karuppaiah Jeyaprakash , Mohamad S. AlSalhi , Sandhanasamy Devanesan

The M. citrifolia, commonly called starvation fruit, plays an essential role in daily dietary intakes, as it contains several vitamins, phytochemicals, and electrolytes. These constituents have several biological activities that are anti-tumor, antibacterial, antiviral, antifungal, and play a role in the immune system. The silver nanoparticles (AgNPs) were synthesized using a more uncomplicated and fast means using the M. citrifolia fruit samples. The Silver ions (Ag+) readily get reduced to (Ag0) to perform M. Citrifolia AgNPs hence the fruit extracts of M. Citrifolia can be considered potential lowering agents. The preliminary confirmation was done qualitatively by change of color into brownish-black, and the color change was observed due to bio-reduction and the Surface Plasmon Resonance (SPR) vibration. It was established by the absorbance peak at 430 nm using UV–Visible spectral analysis. Scanning Electron microscopy (SEM) showed the particle size ranging from 12 to 26 nm. Fourier-transform infrared spectroscopy (FTIR) confirmed the presence of the functional groups from synthesized M. citrifolia AgNPs. The biochemical studies were supported by the effect of antioxidant and anticancer properties of M. citrifolia AgNPs. The pathological changes were studied using hematoxylin, and Eosin staining in Albino mice, which was no tumor (Ehrlich ascites carcinoma) cell invasion exhibited in Fluorouracil treated group. The present investigation proves that the M. citrifolia fruit extract derived AgNPs is a promising antioxidant agent to treat liver cancer.



中文翻译:

巴戟天果实合成的银纳米颗粒对艾氏腹水癌小鼠的抗癌和抗氧化作用。

枸杞分支杆菌(M. citrifolia)通常被称为饥饿水果,因为它含有多种维生素,植物化学物质和电解质,因此在日常饮食中起着至关重要的作用。这些成分具有抗肿瘤,抗菌,抗病毒,抗真菌等多种生物学活性,并在免疫系统中起作用。所述银纳米颗粒(的AgNPs)用使用一个更简单的和快速的方法合成M.戟天果实的样品。银离子(Ag +)容易地获得减少到(AG0)以执行M.戟天的AgNPs因此的水果提取物M.达圣契弗利亚可以被认为是潜在的降低剂。通过将颜色改变为棕黑色定性地进行初步确认,并且由于生物还原和表面等离子体共振(SPR)振动而观察到颜色变化。它是通过使用紫外可见光谱分析在430 nm处的吸收峰确定的。扫描电子显微镜(SEM)显示粒度为12至26nm。傅里叶变换红外光谱(FTIR)证实从合成的官能团的存在M.戟天的AgNPs 枸杞抗氧化和抗癌特性的研究为生化研究提供了支持AgNPs。使用苏木精和伊红染色研究了白化小鼠的病理学变化,在氟尿嘧啶治疗组中未表现出肿瘤(艾氏腹水癌)细胞浸润。本研究证明,M.诺丽果提取而得的AgNPs是一个有前途的抗氧化剂治疗肝癌。

更新日期:2020-09-29
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