Objective

To determine the cardiopulmonary effects of etorphine and thiafentanil for immobilization of blesbok.

Study design

Blinded, randomized, two-way crossover study.

Animals

A group of eight adult female blesbok.

Methods

Animals were immobilized twice, once with etorphine (0.09 mg kg^–1) and once with thiafentanil (0.09 mg kg^–1) administered intramuscularly by dart. Immobilization quality was assessed and analysed by Wilcoxon signed-rank test. Time to final recumbency was compared between treatments by one-way analysis of variance. Cardiopulmonary effects including respiratory rate (ƒ_R), arterial blood pressures and arterial blood gases were measured. A linear mixed model was used to assess the effects of drug treatments over the 40 minute immobilization period. Significant differences between treatments, for treatment over time as well as effect of treatment by time on the variables, were analysed (p < 0.05).

Results

There was no statistical difference (p = 0.186) between treatments for time to recumbency. The mean ƒ_R was lower with etorphine (14 breaths minute^–1) than with thiafentanil (19 breaths minute^–1, p = 0.034). The overall mean PaCO₂ was higher with etorphine [45 mmHg (6.0 kPa)] than with thiafentanil [41 mmHg (5.5 kPa), p = 0.025], whereas PaO₂ was lower with etorphine [53 mmHg (7.1 kPa)] than with thiafentanil [64 mmHg (8.5 kPa), p < 0.001]. The systolic arterial pressure measured throughout all time points was higher with thiafentanil than with etorphine (p = 0.04). The difference varied from 30 mmHg at 20 minutes after recumbency to 14 mmHg (standard error difference 2.7 mmHg) at 40 minutes after recumbency. Mean and diastolic arterial pressures were significantly higher with thiafentanil at 20 and 25 minute measurement points only (p < 0.001).

Conclusions

Both drugs caused clinically relevant hypoxaemia; however, it was less severe with thiafentanil. Ventilation was adequate. Hypertension was greater and immobilization scores were lower with thiafentanil.

中文翻译：

---

在化学固定blesbok（Damaliscus pygargus phillipsi）过程中，依托啡肽和噻芬太尼的一些心肺作用比较

客观的

确定埃托啡和噻芬太尼对 blesbok 固定的心肺作用。

学习规划

盲法、随机、双向交叉研究。

动物

一组八只成年雌性长尾羚。

方法

动物用埃托啡固定两次，一次（0.09毫克千克^-1）次，用thiafentanil（0.09毫克千克^-1）通过镖肌内给药。通过 Wilcoxon 符号秩检验评估和分析固定质量。通过单向方差分析比较治疗之间的最终卧床时间。测量了包括呼吸频率 (ƒ _R )、动脉血压和动脉血气在内的心肺效应。使用线性混合模型来评估药物治疗在 40 分钟固定期间的效果。分析了治疗之间的显着差异，即治疗随时间的变化以及治疗随时间变化对变量的影响（p < 0.05）。

结果

 对于卧床时间，治疗之间没有统计学差异（p = 0.186）。使用依托啡（14 次呼吸分钟^–1）的平均 ƒ _R低于使用噻芬太尼（19 次呼吸分钟^–1，p  = 0.034）。使用依托啡肽 [45 mmHg (6.0 kPa)]的总体平均 PaCO ₂高于使用噻芬太尼 [41 mmHg (5.5 kPa)，p  = 0.025]，而使用埃托啡[53 mmHg (7.1 kPa)] 的PaO ₂低于使用埃托啡[53 mmHg (7.1 kPa)]噻芬太尼 [64 mmHg (8.5 kPa)，p < 0.001]。在所有时间点测量的收缩动脉压均高于噻芬太尼组（p = 0.04）。差异从卧床后 20 分钟的 30 mmHg 到卧床 40 分钟后的 14 mmHg（标准误差差 2.7 mmHg）不等。仅在 20 和 25 分钟测量点，噻芬太尼的平均和舒张动脉压显着升高（p < 0.001）。

结论

两种药物均引起临床相关的低氧血症；然而，噻芬太尼没有那么严重。通风是足够的。噻芬太尼的高血压更高，制动评分更低。