Gliomas are aggressive brain tumors with high mortality rate. Over the past several years, non-coding RNAs, specifically the long non-coding RNAs (lncRNAs), have emerged as biomarkers of considerable interest. Emerging data reveals distinct patterns of expressions of several lncRNAs in the glioma tissues, relative to their expression in normal brains. This has led to the speculation for putative exploitation of lncRNAs as diagnostic biomarkers as well as biomarkers for targeted therapy. With a focus on lncRNAs that have shown promise as epigenetic biomarkers in the proliferation, migration, invasion, angiogenesis and metastasis in various glioma models, we discuss several such lncRNAs. The data from cell line / animal model-based studies as well as analysis from human patient samples is presented for the most up-to-date information on the topic. Overall, the information provided herein makes a compelling case for further evaluation of lncRNAs in clinical settings.

胶质瘤是具有高死亡率的侵袭性脑肿瘤。在过去几年中，非编码 RNA，特别是长链非编码 RNA (lncRNA)，已成为引起人们极大兴趣的生物标志物。新兴数据揭示了神经胶质瘤组织中几种 lncRNA 的表达模式与它们在正常大脑中的表达不同。这导致推测将 lncRNA 作为诊断生物标志物以及靶向治疗的生物标志物进行开发。重点关注在各种神经胶质瘤模型中已显示出在增殖、迁移、侵袭、血管生成和转移中作为表观遗传生物标志物的前景的 lncRNA，我们讨论了几种此类 lncRNA。提供来自基于细胞系/动物模型的研究的数据以及来自人类患者样本的分析，以获取有关该主题的最新信息。