The photopic negative response of the electroretinogram reflects retinal ganglion cell function and consequently aids diagnosis of optic nerve diseases including glaucoma. In this study, we assessed the efficacy of stimulation parameters for electroretinographic recordings of the multifocal photopic negative response (mfPhNR) for the detection of glaucoma and compared the diagnostic accuracy of electrophysiological, structural and functional measures of glaucoma. We compared the diagnostic performance of the mfPhNR for 6 different stimulation rates in a cohort of 24 controls, 10 glaucoma suspects (GLA S ) and 16 glaucoma participants (GLA G). A cross-modal comparison of the mfPhNR/b wave ratio was performed with the pattern electroretinogram (PERG), and the peripapillary retinal nerve fiber layer (pRNFL) thickness. These analyses were based on area under curves (AUC) obtained from receiver-operating-characteristics (ROC) and step-wise regression analyses. We found that compared to the other mfPhNR-conditions, the PhNR/b-wave ratio for the fastest stimulation condition had the highest AUC for GLA S (.84, P = .008, 95%CI: .71- .98), while the other modalities, i.e., PERG-amplitude and pRNFL had AUCs of .78 (P = .039), and .74 (P >.05), respectively. For GLA G , the respective AUCs were 0.78 (P = .002), .85 (P < .001) and .87 (P < .001). pRNFL was the significant predictor for both mfPhNR/b-wave ratio [t (48) = 4, P .0002] and for PERG amplitude [t (48) = 3.4, P .001]. In conclusion, fast mfPhNR protocols outperform other multifocal PhNR protocols in the identification of glaucomatous damage especially for GLA S and thus aid the early detection of glaucoma, indicating its value as surrogate marker of early stage ganglion cell dysfunction.

视网膜电图的可见光负响应反映了视网膜神经节细胞的功能，因此有助于诊断包括青光眼在内的视神经疾病。在这项研究中，我们评估了电刺激视网膜电图记录多焦距光敏阴性反应（mfPhNR）来检测青光眼的功效，并比较了电生理，结构和功能性青光眼的诊断准确性。我们比较了24名对照组，10名青光眼可疑者（GLA S）和16名青光眼参与者（GLA G）对6种不同刺激率的mfPhNR的诊断性能。使用模式视网膜电图（PERG）和乳头周围视网膜神经纤维层（pRNFL）厚度进行mfPhNR / b波比的交叉模态比较。这些分析基于从接收者操作特征（ROC）和逐步回归分析获得的曲线下面积（AUC）。我们发现，与其他mfPhNR条件相比，最快刺激条件下的PhNR / b波比对GLA S的AUC最高（.84，P = .008，95％CI：.71- .98），而其他方式，即PERG振幅和pRNFL的AUC分别为0.78（P = .039）和.74（P> .05）。对于GLA G，相应的AUC分别为0.78（P = .002）、. 85（P <.001）和.87（P <.001）。对于mfPhNR / b波比[t（48）= 4，P .0002]和PERG振幅[t（48）= 3.4，P .001]，pRNFL是重要的预测指标。结论，