Abstract N-(2-hydroxypropyl)methacrylamide-based block copolymers (pHPMA) have received attention due to their hydrophilicity, non-immunogenicity, biocompatibility and possibility of functionalization by various ligands. In addition to being hydrophilic polymeric form, HPMA monomers can be modified with hydrophobic moieties and the resultant amphiphilic polymers could self-assemble to form nanoparticles. In addition to entrapping drugs physically in the nanoparticles, multiple drug molecules can be conjugated on the monomers. The review covers the synthetic strategies, structural and chemical aspects of various functionalized pHPMA, and current state of the art research on development of pHPMA-based potential nanocarriers for various drugs. The design of grafted/branched pHPMA, pro-drug approach, star-shaped polymers and stimuli-sensitive pHMPA-based nanoparticles has been discussed. Overall, the review portrays the development of novel HPMA-based polymeric systems and their application in drug delivery platform.

中文翻译：

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基于 HPMA 的嵌段共聚物纳米粒子在药物输送中的应用的当前发展趋势

摘要 N-(2-羟丙基)甲基丙烯酰胺基嵌段共聚物(pHPMA)因其亲水性、非免疫原性、生物相容性和各种配体功能化的可能性而受到关注。除了作为亲水聚合物形式外，HPMA 单体还可以用疏水部分进行改性，所得的两亲聚合物可以自组装形成纳米颗粒。除了将药物物理包裹在纳米颗粒中之外，多个药物分子还可以结合在单体上。该综述涵盖了各种功能化 pHPMA 的合成策略、结构和化学方面，以及当前开发基于 pHPMA 的各种药物潜在纳米载体的最新研究。接枝/支化 pHPMA 的设计，前药方法，已经讨论了星形聚合物和刺激敏感的基于 pHMPA 的纳米粒子。总体而言，该综述描述了基于 HPMA 的新型聚合物系统的开发及其在药物递送平台中的应用。