BACKGROUND The role of inflammation in the early development of vascular dysfunction remains complex. Interleukin-6 (IL-6) and C-reactive protein (CRP) can cause an acute imbalance in the von Willebrand factor (vWF)-ADAMTS13 interaction, indicating a possible link between markers of haemostasis and low-grade inflammation. To better understand these inter-relationships in the early phases of disease development, we investigated whether vWF and ADAMTS13 associate with the pro-inflammatory markers, IL-6 and CRP in healthy young adults. We considered the role of blood types, sex and race on these relationships. METHODS In healthy black and white men and women (n = 1113; 24 ± 5 years; no previous diagnosis or medication use for chronic diseases) we analysed von Willebrand factor antigen (vWFag), ADAMTS13, IL-6 and CRP, and grouped blood types as non-O (A, B and AB) and O. Covariates included socioeconomic status, age, estimated glomerular filtration rate, 24-hour systolic blood pressure, waist circumference, glucose, total cholesterol, platelet count, γ-glutamyl transferase and total energy expenditure. RESULTS In the total group, vWFag was highest in the third tertile of both IL-6 and CRP (p ≤ 0.014), while ADAMTS13 was lowest in the third compared to the first IL-6 tertile (p = 0.006). In multivariate regression, vWFag associated positively with IL-6 (Adj R2 = 0.169; β = 0.123; p = 0.001) and CRP (Adj R2 = 0.163; β=0.094; p = 0.019) in the total group, in the O blood group (all p ≤ 0.051) and white men (all p ≤ 0.035). ADAMTS13 associated negatively with IL-6 (Adj R2 = 0.053; β = -0.154; p = 0.015) and CRP (Adj R2 = 0.055; β = -0.177; p = 0.009), only in the O blood group. CONCLUSIONS Markers of haemostasis associated independently with low-grade inflammation in the O type blood group and white men. An interplay between the haemostatic and inflammatory systems may already exist in young healthy adults and is dependent on blood groups, sex and race. This extends our understanding on the role of inflammation in the early development of vascular dysfunction prior to cardiovascular compromise.

中文翻译：

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Von Willebrand 因子、其裂解蛋白酶 (ADAMTS13) 和年轻人的炎症：African-PREDICT 研究

背景炎症在血管功能障碍的早期发展中的作用仍然很复杂。白细胞介素 6 (IL-6) 和 C 反应蛋白 (CRP) 可导致血管性血友病因子 (vWF)-ADAMTS13 相互作用的严重失衡，表明止血标志物与低度炎症之间可能存在联系。为了更好地了解疾病发展早期阶段的这些相互关系，我们研究了 vWF 和 ADAMTS13 是否与健康年轻人中的促炎标志物 IL-6 和 CRP 相关。我们考虑了血型、性别和种族在这些关系中的作用。方法 在健康的黑人和白人男性和女性（n = 1113；24 ± 5 岁；既往无慢性病诊断或药物使用）中，我们分析了血管性血友病因子抗原 (vWFag)、ADAMTS13、IL-6 和 CRP，和分组血型为非 O（A、B 和 AB）和 O。协变量包括社会经济地位、年龄、估计的肾小球滤过率、24 小时收缩压、腰围、葡萄糖、总胆固醇、血小板计数、γ-谷氨酰转移酶和总能量消耗。结果 在整个组中，vWFag 在 IL-6 和 CRP 的第三个三分位数中最高（p ≤ 0.014），而 ADAMTS13 在第三个中最低，与第一个 IL-6 三分位数相比（p = 0.006）。在多元回归中，vWFag 与 O 血总组中的 IL-6（Adj R2 = 0.169；β = 0.123；p = 0.001）和 CRP（Adj R2 = 0.163；β=0.094；p = 0.019）呈正相关组（所有 p ≤ 0.051）和白人男性（所有 p ≤ 0.035）。ADAMTS13 与 IL-6（Adj R2 = 0.053；β = -0.154；p = 0.015）和 CRP（Adj R2 = 0.055；β = -0.177；p = 0.009）呈负相关，仅在 O 血型中。结论 止血标志物与 O 型血型和白人男性的低度炎症独立相关。止血和炎症系统之间的相互作用可能已经存在于年轻健康的成年人中，并且取决于血型、性别和种族。这扩展了我们对炎症在心血管损害之前血管功能障碍早期发展中的作用的理解。