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One-Pot Synthesis of Papaverine Hydrochloride and Identification of Impurities
Russian Journal of Organic Chemistry ( IF 0.8 ) Pub Date : 2020-09-10 , DOI: 10.1134/s1070428020070258
Wen-Shuai Yu , Ze-Nong Wu , Zeng-Feng Qiu , Chun-Jie Zhao , Fu-Li Zhang , Zhe-Zhou Yang

Abstract

A one-pot synthesis of papaverine hydrochloride with 99.6% purity was performed using xylene as solvent for the entire process. The critical parameters of each step, as well as the impurities generated, were identified. The overall yield was improved to 63%. The proposed synthetic procedure is suitable for industrial production.



中文翻译:

盐酸罂粟碱的一锅法合成及杂质鉴定

摘要

在整个过程中,使用二甲苯作为溶剂,一锅法合成了纯度为99.6%的盐酸罂粟碱。确定了每个步骤的关键参数以及所产生的杂质。总产率提高到63%。拟议的合成程序适用于工业生产。

更新日期:2020-09-11
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