Abstract

Chiral oxazoline ligands containing an aromatic ring were prepared from norephedrine and pyrrole-2-carbonitrile or 2-hydroxybenzoyl chloride. The synthesized ligands were used in the copper-catalyzed asymmetric addition of diethylzinc to aromatic aldehydes to provide optically active 1-arylpropan-1-ols with high conversion (92%) and enantioselectivity (up to 99% ee).

中文翻译：

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使用手性恶唑啉基配体将二乙基锌对映选择性加成到芳香醛上

摘要

由去氧麻黄碱和吡咯-2-腈或2-羟基苯甲酰氯制备含有芳环的手性恶唑啉配体。合成的配体用于铜催化的二乙基锌向芳族醛的不对称加成反应，以提供具有高转化率（92％）和对映选择性（高达99％ee）的光学活性1-芳基丙烷-1-醇。