In recent times, radiation therapy (RT) involving ultra-high dose rates of ionizing radiation, known as FLASH-RT, has been of great interest. Through this technology, the radiation dose can be delivered almost instantaneously within milliseconds. Many in vitro and in vivo studies have demonstrated that FLASH-RT can significantly improve normal tissue tolerance from radiation induced toxicity; this improvement is called the FLASH effect. Very recently, encouraging results from FLASH-RT on human patients have been reported, which has extended the applicability of FLASH-RT to clinical practice. In this review, we will discuss the results of the current research on FLASH-RT and consider the challenges to be overcome prior to the clinical application of FLASH-RT.

中文翻译：

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闪光放射治疗：放射治疗的潜在创新驱动力

最近，涉及超高剂量率电离辐射的放射治疗 (RT)，称为 FLASH-RT，引起了人们极大的兴趣。通过这项技术，辐射剂量可以在几毫秒内几乎瞬间传递。许多体外和体内研究表明，FLASH-RT 可以显着提高正常组织对辐射诱导毒性的耐受性；这种改进称为 FLASH 效果。最近，有报道称 FLASH-RT 在人类患者身上取得了令人鼓舞的结果，这将 FLASH-RT 的适用性扩展到了临床实践。在这篇综述中，我们将讨论当前 FLASH-RT 研究的结果，并考虑在 FLASH-RT 临床应用之前需要克服的挑战。