We analyzed the expression of genes encoding proteins involved in cytoskeleton remodeling (RND3, SNAI1, vimentin, cofilin, adenylate cyclase-associated protein 1, ezrin, and profilin) depending on the level of expression of protein phosphatase 1B (PPM1B) mRNA on the example of squamous cell carcinoma of the larynx and hypopharynx. Against the background of a high level of PPM1B expression, a significantly high level of profilin expression was noted. Metastasis correlated with the level of snai1 expression, while relapse after combination treatment was negatively associated with the level of vimentin expression. The obtained new data can reflect molecular peculiarities of the tumor growth in squamous cell carcinoma of the larynx and hypopharynx.

中文翻译：

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喉、下咽鳞状细胞癌中蛋白磷酸酶1B mRNA表达水平与细胞骨架重塑相关蛋白的关系

我们根据示例中蛋白磷酸酶 1B (PPM1B) mRNA 的表达水平分析了编码参与细胞骨架重塑的蛋白质（RND3、SNAI1、波形蛋白、cofilin、腺苷酸环化酶相关蛋白 1、ezrin 和 profilin）的表达喉和下咽部鳞状细胞癌。在高水平 PPM1B 表达的背景下，注意到了显着高水平的 profilin 表达。转移与 snai1 表达水平相关，而联合治疗后复发与波形蛋白表达水平呈负相关。获得的新数据可以反映喉部和下咽部鳞状细胞癌肿瘤生长的分子特征。