Retinoblastoma is the commonest eye cancer occurring in the pediatric population. Circular RNAs (circRNAs) are essential regulators of tumorigenesis and development. The current experiment delves into the function and molecular basis of hsa_circ_0000034 in retinoblastoma progression. In the study, these series of experiments noted an upregulation of hsa_circ_0000034 in retinoblastoma cell lines and tissues. Retinoblastoma patients with raised hsa_circ_0000034 expressions were more likely to possess a more progressive International Integrated Reporting Council (IIRC) stage and optic nerve invasion. hsa_circ_0000034 knockdown caused a marked suppression in the proliferation and invasion of retinoblastoma cells in vitro. Mechanistically, hsa_circ_0000034 appeared to serve as a competitive endogenous RNA (ceRNA) in retinoblastoma through miR-361-3p sponging. In conclusion, our data proved that hsa_circ_0000034 promoted the oncogenicity of retinoblastoma via regulation of miR-361-3p expression, a finding that may contribute toward retinoblastoma therapeutics.

中文翻译：

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环状 RNA hsa_circ_0000034 通过海绵状 microRNA-361-3p 促进视网膜母细胞瘤的进展。

视网膜母细胞瘤是儿科人群中最常见的眼癌。环状RNA（circRNA）是肿瘤发生和发展的重要调节因子。目前的实验深入研究了 hsa_circ_0000034 在视网膜母细胞瘤进展中的功能和分子基础。在这项研究中，这些系列的实验注意到 hsa_circ_0000034 在视网膜母细胞瘤细胞系和组织中上调。具有升高的 hsa_circ_0000034 表达的视网膜母细胞瘤患者更有可能具有更进步的国际综合报告委员会 (IIRC) 分期和视神经侵犯。hsa_circ_0000034 敲低引起体外视网膜母细胞瘤细胞增殖和侵袭的显着抑制。从机制上讲，hsa_circ_0000034 似乎通过 miR-361-3p 海绵作用在视网膜母细胞瘤中充当竞争性内源性 RNA (ceRNA)。总之，我们的数据证明 hsa_circ_0000034 通过调节 miR-361-3p 表达促进了视网膜母细胞瘤的致癌性，这一发现可能有助于视网膜母细胞瘤的治疗。