INTRODUCTION Clinical complications in sickle cell anemia (SCA) are heterogeneous and involve several molecules. It has been suggested that SCA individuals present a dyslipidemic phenotype and that lipid parameters are associated with severe clinical complications, such as pulmonary hypertension. We sought to investigate associations between lipid parameters and clinical manifestations, as well as other laboratory parameters in a population of pediatric SCA patients. METHODS Our cross-sectional evaluation included 126 SCA patients in steady state and who were not undergoing lipid-lowering therapy. Hematological and biochemical parameters were characterized, and previous clinical manifestations were investigated. RESULTS Total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels were increased in patients with a previous history of pneumonia, which also positively correlated with HbS levels. Decreased LDL-C levels were also associated with leg ulcers and anemia. Elevated high-density lipoprotein cholesterol (HDL-C) levels were associated with pain crises, increased viscosity, and decreased hemolysis. Several studies have determined that lipids play a role in the vascular impairment seen in SCA, which was corroborated by our findings. CONCLUSIONS In sum, our results suggest that total cholesterol, HDL-C, and LDL-C levels are associated with hemolysis and anemia markers and, most importantly, with clinical complications related to vasculopathy in SCA.

中文翻译：

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SCA儿童血脂及临床表现的调查。

简介 镰状细胞性贫血 (SCA) 的临床并发症是异质的，涉及多个分子。有人提出，SCA 个体呈现血脂异常表型，并且血脂参数与严重的临床并发症有关，例如肺动脉高压。我们试图调查儿童 SCA 患者人群中脂质参数与临床表现以及其他实验室参数之间的关联。方法 我们的横断面评估包括 126 名处于稳定状态且未接受降脂治疗的 SCA 患者。对血液学和生化参数进行了表征，并调查了以前的临床表现。结果 有肺炎病史的患者总胆固醇和低密度脂蛋白胆固醇 (LDL-C) 水平升高，这也与 HbS 水平呈正相关。降低的 LDL-C 水平也与腿部溃疡和贫血有关。高密度脂蛋白胆固醇 (HDL-C) 水平升高与疼痛危象、粘度增加和溶血减少有关。几项研究已经确定，脂质在 SCA 中所见的血管损伤中起作用，我们的研究结果证实了这一点。结论 总之，我们的结果表明，总胆固醇、HDL-C 和 LDL-C 水平与溶血和贫血标志物有关，最重要的是，与 SCA 中血管病变相关的临床并发症有关。降低的 LDL-C 水平也与腿部溃疡和贫血有关。高密度脂蛋白胆固醇 (HDL-C) 水平升高与疼痛危象、粘度增加和溶血减少有关。几项研究已经确定，脂质在 SCA 中所见的血管损伤中起作用，我们的研究结果证实了这一点。结论 总之，我们的结果表明，总胆固醇、HDL-C 和 LDL-C 水平与溶血和贫血标志物有关，最重要的是，与 SCA 中血管病变相关的临床并发症有关。降低的 LDL-C 水平也与腿部溃疡和贫血有关。高密度脂蛋白胆固醇 (HDL-C) 水平升高与疼痛危象、粘度增加和溶血减少有关。几项研究已经确定，脂质在 SCA 中所见的血管损伤中起作用，我们的研究结果证实了这一点。结论 总之，我们的结果表明，总胆固醇、HDL-C 和 LDL-C 水平与溶血和贫血标志物有关，最重要的是，与 SCA 中血管病变相关的临床并发症有关。我们的研究结果证实了这一点。结论 总之，我们的结果表明，总胆固醇、HDL-C 和 LDL-C 水平与溶血和贫血标志物有关，最重要的是，与 SCA 中血管病变相关的临床并发症有关。我们的研究结果证实了这一点。结论 总之，我们的结果表明，总胆固醇、HDL-C 和 LDL-C 水平与溶血和贫血标志物有关，最重要的是，与 SCA 中血管病变相关的临床并发症有关。