There is relatively little research on aging with HIV and wellbeing in sub-Saharan Africa. A cross-sectional survey was implemented in Malawi; eligible respondents were ≥ 30 years old and on ART for ≥ 2 years. Univariate and multiple regression analyses were stratified by age (younger adults: aged 30–49; older adults: aged ≥ 50) and gender. The median age was 51 years (total sample n = 134). Viral suppression was less common among older respondents (83.7% versus 93.0% among younger respondents) although not significant in adjusted models. Despite exhibiting worse physical and cognitive functioning (any physical functioning challenge: aOR 5.35, p = 0.02; cognitive functioning score difference: − 0.89 points, p = 0.04), older adults reported less interpersonal violence and fewer depressive symptoms (mild depression: aOR 0.23 p = 0.002; major depression: aOR 0.16, p = 0.004); in gender-stratified models, these relationships were significant only for females. More research is needed to disentangle the interplay between aging, gender and HIV in high-burden contexts and develop interventions to support comprehensive wellbeing in this population.

关于撒哈拉以南非洲地区艾滋病毒老龄化和福祉的研究相对较少。在马拉维进行了一项横断面调查；符合条件的受访者年龄≥30岁且接受ART治疗≥2年。单变量和多元回归分析按年龄（年轻人：30-49 岁；老年人：≥ 50 岁）和性别进行分层。中位年龄为 51 岁（样本总数 n = 134）。病毒抑制在老年受访者中不太常见（83.7% 对年轻受访者为 93.0%），尽管在调整后的模型中并不显着。尽管身体和认知功能较差（任何身体功能挑战：aOR 5.35，p = 0.02；认知功能得分差异：− 0.89 分，p = 0.04），但老年人报告的人际暴力和抑郁症状较少（轻度抑郁：aOR 0.23） p = 0.002；重度抑郁症：aOR 0.16，p = 0.004)；在性别分层模型中，这些关系仅对女性有意义。需要更多的研究来理清高负担背景下老龄化、性别和艾滋病毒之间的相互作用，并制定干预措施来支持该人群的全面福祉。