The first total synthesis of (±)-neocaryachine (1) was achieved using a radical cyclization to produce the dibenzo-9-azabicyclo[3.3.1]nonane pavine skeleton, following a Bischler–Napieralski reaction to construct an intermediate benzylisoquinoline. The resulting racemic mixture was separated by chiral column chromatography to provide pure (+)- and (−)-1.

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中文翻译：

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猪生物碱（±）-新烟碱的首次全合成及其光学拆分。

在Bischler-Napieralski反应构建中间体苄基异喹啉之后，利用自由基环化反应生成了二苯并9-氮杂双环[3.3.1]壬烷骨架，首次实现了（±）-新烟碱（1）的首次合成。通过手性柱色谱分离得到的外消旋混合物，得到纯的（+）-和（-）- 1。

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