Two new macrolides, iriomoteolides-14a (1) and 14b (2) have been isolated from the marine dinoflagellate Amphidinium species (strain KCA09057). Compounds 1 and 2 are 15-membered macrolides, which are structural analogs of amphidinolides O (3) and P (4). The structures of 1 and 2 were assigned on the basis of detailed NMR analyses and chemical conversion studies. Compounds 1 and 2 showed moderate cytotoxic activity against human cervix adenocarcinoma HeLa cells.

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中文翻译：

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Iriomoteolides-14a和14b，来自海洋鞭毛双歧杆菌物种的新型细胞毒性15元大环内酯。

两种新的大环内酯类化合物，iriomoteolides-14a（1）和14b（2）已从海洋双鞭毛的两栖动物物种（菌株KCA09057）中分离出来。化合物1和2是15元大环内酯，它们是两性化合物O（3）和P（4）的结构类似物。1和2的结构是根据详细的NMR分析和化学转化研究确定的。化合物1和2对人宫颈腺癌HeLa细胞显示出中等的细胞毒活性。

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