The advent of the genomic era has opened up enormous possibilities for the discovery of new natural products. Also known as specialized metabolites, these compounds produced by bacteria, fungi, and plants have long been sought for their bioactive properties. Innovations in both DNA sequencing technologies and bioinformatics now allow the wealth of sequence data to be mined at both the genome and metagenome levels for new specialized metabolites. However, a key problem that remains is rapidly and efficiently linking these identified genes to their corresponding compounds. Within this review, we provide specific examples of studies that have used the power of genomic or metagenomic data to overcome these problems and identify new small molecules and their biosynthetic pathways.

中文翻译：

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通过微生物基因组挖掘发现天然产物。

基因组时代的到来为发现新的天然产物开辟了巨大的可能性。这些由细菌、真菌和植物产生的化合物也称为专门的代谢物，长期以来一直因其生物活性特性而备受关注。DNA 测序技术和生物信息学的创新现在允许在基因组和宏基因组水平上挖掘大量序列数据，以获取新的专门代谢物。然而，仍然存在的一个关键问题是快速有效地将这些已识别的基因与其相应的化合物联系起来。在这篇综述中，我们提供了一些研究的具体例子，这些研究利用基因组或宏基因组数据的力量来克服这些问题并识别新的小分子及其生物合成途径。