Obesity and cancer cachexia are diseases at opposite ends of the BMI. However, despite the apparent dichotomy, these pathologies share some common underlying mechanisms that lead to profound metabolic perturbations. Insulin resistance, adipose tissue lipolysis, skeletal muscle atrophy and systemic inflammation are key players in both diseases. Several strategies for pharmacological treatments have been employed in obesity and cancer cachexia but demonstrated only limited effects. Therefore, there is still a need to develop novel, more effective strategies. In this review we summarize existing therapies and discuss potential novel strategies that could arise by bridging common aspects between obesity and cachexia. We discuss the potential role of macrophage manipulation and the modulation of inflammation by targeting Nuclear Receptors (NRs) as potential novel therapeutic strategies.

中文翻译：

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利用肥胖和癌症恶病质的共同方面来制定未来的治疗策略。

肥胖和癌症恶病质是 BMI 两端的疾病。然而，尽管存在明显的二分法，但这些病理共享一些共同的潜在机制，导致严重的代谢紊乱。胰岛素抵抗、脂肪组织脂肪分解、骨骼肌萎缩和全身炎症是这两种疾病的关键因素。几种药物治疗策略已用于肥胖症和癌症恶病质，但仅显示出有限的效果。因此，仍然需要开发新的、更有效的策略。在这篇综述中，我们总结了现有的治疗方法，并讨论了通过弥合肥胖和恶病质之间的共同点可能产生的潜在新策略。