In this work, we utilized spontaneously hypertensive rats (SHR) and Wister Kyoto rats (WKY), from which the SHR was established, to evaluate the effects of whole-body acute radiation on the cardiovascular system at doses from 0 to 4 Gy. In the irradiated SHR, the systolic blood pressure (SBP) increased with increasing dose, while body weight gain decreased with increasing radiation dose. Furthermore, pathological observations of SHR demonstrated that the number of rats with cystic degeneration in the liver increased with increasing dose. The effects observed among SHR, such as increased SBP and retardation of body weight gain, appear very similar to those observed in Japanese atomic bomb survivors. In contrast, the SBP among WKY did not change relative to dose; the body weight, however, did change, as in the SHR. Therefore, the association between radiation exposure and SBP, but not between radiation exposure and retardation of body weight gain, may be affected by genetic background, as evident from strain difference. These results suggest that the SHR and WKY animal models may be useful for studying radiation effects on non-cancer diseases including circulatory diseases, chronic liver disease and developmental retardation.

中文翻译：

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辐射对自发性高血压大鼠模型血压和体重的影响。辐射对血压的影响是否受遗传背景影响？

在这项工作中，我们利用建立了SHR的自发性高血压大鼠（SHR）和Wister Kyoto大鼠（WKY）评估了0至4 Gy剂量的全身急性放射对心血管系统的影响。在受辐照的SHR中，收缩压（SBP）随着剂量的增加而增加，而体重增加随辐射剂量的增加而降低。此外，SHR的病理学观察表明，肝脏中具有囊性变性的大鼠数量随剂量增加而增加。在SHR中观察到的效果，例如SBP升高和体重增加延迟，看起来与日本原子弹幸存者中观察到的效果非常相似。相比之下，WKY患者的SBP相对于剂量没有变化。然而，体重确实发生了变化，就像在SHR中一样。因此，从菌株差异可以明显看出，辐射背景与SBP之间的关联，但不受辐射暴露与体重增加延迟之间的关联，可能受到遗传背景的影响。这些结果表明，SHR和WKY动物模型可用于研究辐射对非癌症疾病（包括循环系统疾病，慢性肝病和发育迟缓）的影响。