In this study, a strain of Trichosporon was isolated from white pseudomembranes and ulcers formed on mucous membranes of pigeon bursas and was identified through gene sequencing. Bacteriostatic actions of Acorus gramineus, Sophora flavescens, Polygonum hydropiper, and Chinese herbal mixture on this species were explored in vitro, and the minimum inhibitory concentration of herbal medicines against Trichosporon was determined through microdilution method. Therapeutic effects of herbal medicines on chickens infected by Trichosporon were studied, whose results showed that minimum inhibitory concentration of A. gramineus was 32 μg/μL, that of S. flavescens was 2 μg/μL, that of P. hydropiper was 120 μg/μL, and that of Chinese herbal mixture was 36 μg/μL. Antibacterial effects of S. flavescens were the best. In accordance with animal experiments, therapeutic effects of Chinese herbal medicines on infected chickens were better than those of fluconazole. The mortality rate of the Chinese herbal medicine treatment group was 33.33%, that of the fluconazole treatment group was 46.67%, and that of the Chinese medicine protection group was 23.33%. The longer the time of Chinese medicine treatments was, the better the treatment effects would be. Glutamic oxaloacetylase values of the serum and liver in the Chinese herbal medicine treatment group were both significantly lower than those of the nontreatment group. From the results, it can be seen that A. gramineus, S. flavescens, P. hydropiper, and Chinese herbal mixture have certain inhibitory effects on Trichosporon spp. Chinese herbal medicine protections in advance could reduce Trichosporon infections.

中文翻译：

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中草药对禽毛孢子菌抑菌作用的研究。


本研究从鸽子法氏囊粘膜上形成的白色假膜和溃疡中分离出一株毛孢子菌，并通过基因测序进行鉴定。考察了石菖蒲、苦参、蓼、中药合剂对该种的体外抑菌作用，并通过微量稀释法测定了中药对毛孢子菌的最低抑菌浓度。研究了中草药对毛孢子菌感染鸡的治疗效果，结果显示，禾草霉最低抑菌浓度为32 μg/μL，苦参最低抑菌浓度为2 μg/μL，水荠最低抑菌浓度为120 μg/μL。 μL，中药合剂为36 μg/μL。苦参的抗菌作用最好。根据动物实验，中草药对感染鸡的治疗效果优于氟康唑。中药治疗组死亡率为33.33%，氟康唑治疗组死亡率为46.67%，中药保护组死亡率为23.33%。中医治疗的时间越长，治疗效果越好。中药治疗组血清和肝脏谷氨酸草酰乙酰酶值均显着低于未治疗组。结果表明，禾谷草、苦参、水荠、中药合剂对毛孢子菌有一定的抑制作用。提前中草药防护可减少毛孢子菌感染。