Mycoplasma gallisepticum (MG) is an important avian pathogen that causes significant economic losses in the poultry industry. Surprisingly, the limited protection and adverse reactions caused by the vaccines, including live vaccines, bacterin-based (killed) vaccines, and recombinant viral vaccines is still a major concern. Mycoplasma gallisepticum strains vary in infectivity and virulence and infection may sometimes unapparent and goes undetected. Although extensive research has been carried out on the biology of this pathogen, information is lacking about the type of immune response that confers protection and selection of appropriate protective antigens and adjuvants. Regardless of numerous efforts focused on the development of safe and effective vaccine for the control of MG, the use of modern DNA vaccine technology selected in silico approaches for the use of conserved recombinant proteins may be a better choice for the preparation of novel effective vaccines. More research is needed to characterize and elucidate MG products modulating MG-host interactions. These products could be used as a reference for the preparation and development of vaccines to control MG infections in poultry flocks.

中文翻译：

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鸡败血支原体疫苗的研究，开发现状和挑战。

鸡支原体支原体（MG）是一种重要的禽类病原体，在禽业中会造成重大的经济损失。令人惊讶地，由疫苗包括活疫苗，基于细菌的（杀死的）疫苗和重组病毒疫苗引起的有限的保护和不良反应仍然是主要关注的问题。鸡毒支原体菌株的感染力和毒力各不相同，感染有时可能不明显，无法发现。尽管已经对该病原体的生物学进行了广泛的研究，但是缺乏有关赋予保护和选择合适的保护性抗原和佐剂的免疫应答类型的信息。无论为开发用于控制MG的安全有效的疫苗而付出了许多努力，利用计算机方法选择的现代DNA疫苗技术来使用保守的重组蛋白可能是制备新型有效疫苗的更好选择。需要更多的研究来表征和阐明调节MG与宿主相互作用的MG产品。这些产品可以用作制备和开发用于控制家禽群中MG感染的疫苗的参考。