The current study was aimed to ascertain the effect of blood lead level on brain tissues in patients with type 2 diabetes. A total of 300 human participants ages 27 to 60 years with type 2 diabetes (n = 150) and healthy individuals (n = 150) were included in this study. The serum samples were used for measuring HbA1c and fasting blood glucose. Blood lead level was measured using flame atomic absorption spectrophotometer. Magnetic resonance imaging sub-analysis was used to assess the brain hyperintensities. Brain hyperintensities were found in 55% of patients with diabetes and 6% of non-diabetic control group subjects. The deep white matter hyperintensities were observed in 45% of diabetic patients, while the subcortical hyperintensities were noted in 10% of cases. Entorhinal cortex changes (31%) and hippocampus changes (42%) were noted in diabetic patients with brain hyperintensities. Diabetic patients with brain hyperintensities showed higher blood lead levels, HbA1c, and fasting blood sugar (p < 0.0001) as compared with healthy volunteers. A higher correlation (R2 = 0.8922) was found between deep white matter hyperintensities' size and blood lead levels. In nutshell, persistence of high blood lead level in diabetic patients may progress to brain hyperintensities which may consequently lead to cognitive, behavioral changes and Alzheimer's disease.

中文翻译：

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高血铅水平：2 型糖尿病患者发生脑高信号的风险增加。

目前的研究旨在确定血铅水平对 2 型糖尿病患者脑组织的影响。本研究共包括 300 名年龄在 27 至 60 岁之间的 2 型糖尿病患者（n = 150）和健康个体（n = 150）。血清样本用于测量 HbA1c 和空腹血糖。使用火焰原子吸收分光光度计测量血铅水平。磁共振成像子分析用于评估脑高信号。在 55% 的糖尿病患者和 6% 的非糖尿病对照组受试者中发现脑高信号。在 45% 的糖尿病患者中观察到深部白质高信号，而在 10% 的病例中观察到皮层下高信号。在脑高信号的糖尿病患者中观察到内嗅皮层变化 (31%) 和海马体变化 (42%)。与健康志愿者相比，患有脑高信号的糖尿病患者显示出更高的血铅水平、HbA1c 和空腹血糖 (p < 0.0001)。在深部白质高信号的大小和血铅水平之间发现了更高的相关性 (R2 = 0.8922)。简而言之，糖尿病患者持续的高血铅水平可能会发展为脑高信号，从而导致认知、行为改变和阿尔茨海默病。8922）被发现在深部白质高信号的大小和血铅水平之间。简而言之，糖尿病患者持续的高血铅水平可能会发展为脑高信号，从而导致认知、行为改变和阿尔茨海默病。8922）被发现在深部白质高信号的大小和血铅水平之间。简而言之，糖尿病患者持续的高血铅水平可能会发展为脑高信号，从而导致认知、行为改变和阿尔茨海默病。