The effects of mental health comorbidities and social support on the HIV pre-exposure prophylaxis (PrEP) care continuum are unknown. We conducted a cross-sectional study of men and transgender individuals, ≥ 18 years-old, with ≥ 2 male or transgender partners, or recent condomless anal intercourse. Surveys assessed demographics, mental health treatment, depressive symptomatology, social support, and PrEP-related social contacts. Logistic regression assessed associations between these factors and PrEP uptake and persistence. Participants (n = 247) were 89% cis-male and 46% African-American. Median age was 27 (IQR:23–33). Thirty-seven percent had ever used PrEP, of whom 18% discontinued use. High depressive symptomology was identified in 11% and 9% were receiving mental health treatment. There were no significant associations between depressive symptoms or mental health treatment on the odds of PrEP uptake or discontinuation. Each additional PrEP contact conferred a greater odds of uptake (aOR:1.24, 95% CI: 1.09–1.42). Network-level targets may produce fruitful interventions to increase PrEP uptake.

心理健康合并症和社会支持对 HIV 暴露前预防 (PrEP) 护理连续性的影响尚不清楚。我们对年龄≥ 18 岁、有≥ 2 个男性或变性伴侣、或最近进行过无套肛交的男性和变性个体进行了一项横断面研究。调查评估了人口统计、心理健康治疗、抑郁症状、社会支持和 PrEP 相关的社会接触。逻辑回归评估了这些因素与 PrEP 摄取和持久性之间的关联。参与者 (n = 247) 89% 是顺式男性，46% 是非裔美国人。中位年龄为 27 岁（IQR：23-33）。37% 的人曾经使用过 PrEP，其中 18% 停止使用。11% 的人患有高度抑郁症状，9% 的人正在接受心理健康治疗。抑郁症状或心理健康治疗与 PrEP 服用或停止的几率之间没有显着关联。每增加一次 PrEP 接触都会带来更大的摄取几率（aOR：1.24，95% CI：1.09–1.42）。网络级目标可能会产生富有成效的干预措施，以提高 PrEP 的采用率。