Circadian rhythms play a vital role in metabolic, hormonal, and immunologic function and are often disrupted in patients in the ICU. Circadian rhythms modulate the molecular machinery that responds to injury and illness which can impact recovery. Potential factors contributing to the alteration in circadian rhythmicity in intensive care unit (ICU) patients include abnormal lighting, noise, altered feeding schedules, extensive patient care interactions and medications. These alterations in circadian rhythms in ICU patients may affect outcomes and therefore, normalization of circadian rhythmicity in critically ill patients may be an important part of ICU care.

中文翻译：

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严重疾病的昼夜节律紊乱。

昼夜节律在代谢，激素和免疫功能中起着至关重要的作用，在ICU患者中经常被打乱。昼夜节律调节分子机制，以响应可能影响恢复的伤害和疾病。重症监护病房（ICU）患者的昼夜节律改变的潜在因素包括照明异常，噪音，进食时间表改变，广泛的患者护理相互作用和药物治疗。ICU患者昼夜节律的这些变化可能会影响预后，因此，危重患者昼夜节律的正常化可能是ICU护理的重要组成部分。