Background and Purpose: Acute ischemic stroke (AIS) with large artery occlusion (LAO) may lead to severe disability or death if not promptly treated. To determine the source of cerebral artery occlusion thrombosis, we studied the pathological components of cerebral artery thrombosis with different etiological classifications to guide clinical formulation of preventive treatment. Materials and Methods: Eighty-eight thrombi from AIS patients with LAO, 12 atrial thrombi from patients with valvular heart disease (VHD), and 11 plaques obtained by carotid endarterectomy (CEA) from patients with carotid artery stenosis were included in this retrospective study. The hematoxylin and eosin-stained specimens were quantitatively analyzed for erythrocytes, white blood cells (WBCs) and fibrin; platelets were shown by immunohistochemistry for CD31. Results: The thrombi of VHD showed the highest percentage of fibrin, followed by those of cardioembolism (CE) and stroke of undetermined etiology (SUE), and these values were higher than those of the other groups. Plaques obtained by CEA showed the highest erythrocyte number, followed by the large artery atherosclerosis (LAA) thrombi, and showed significantly noticeable differences between other stroke subtypes. The proportions of fibrin and erythrocytes in the thrombi of CE and SUE were most similar to those in the thrombi of VHD, and the LAA thrombi were the closest to those obtained by CEA. CE thrombi and CEA plaques had a higher percentage of WBCs than thrombi of other stroke thrombus subtypes and VHD. Conclusions: CE and most cryptogenic thrombi may originate from the heart, and the formation of carotid atherosclerotic plaques may be related to atherosclerotic cerebral embolism. Inflammation may be involved in their formation.

中文翻译：

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大动脉闭塞性脑血栓，瓣膜性心脏病心房血栓和颈动脉内膜切除斑块之间的病理组成差异。

背景与目的：如果不及时治疗，伴有大动脉闭塞（LAO）的急性缺血性中风（AIS）可能导致严重的残疾或死亡。为了确定脑动脉血栓形成的来源，我们研究了不同病因分类的脑动脉血栓形成的病理成分，以指导预防性治疗的临床制定。材料与方法：这项回顾性研究包括来自AIS的LAO患者的88个血栓，来自瓣膜性心脏病（VHD）的患者的12个心房血栓以及通过颈动脉内膜切除术（CEA）从颈动脉狭窄患者中获得的11个斑块。对苏木精和曙红染色的标本进行了红细胞，白细胞（WBCs）和血纤蛋白的定量分析。通过CD31的免疫组织化学显示血小板。结果：VHD的血栓显示出最高的血纤蛋白百分比，其次是心脏栓塞（CE）和病因未明（SUE），这些值均高于其他组。通过CEA获得的斑块显示出最高的红细胞数量，其次是大动脉粥样硬化（LAA）血栓，并且在其他中风亚型之间显示出明显的差异。CE和SUE的血栓中血纤蛋白和红细胞的比例与VHD的血栓中的比例最相似，而LAA血栓最接近CEA。CE血栓和CEA斑块的白细胞百分比高于其他中风血栓亚型和VHD的血栓。结论：CE和大多数隐性血栓可能起源于心脏，而颈动脉粥样硬化斑块的形成可能与动脉粥样硬化性脑栓塞有关。炎症可能与它们的形成有关。